Impact of Lysine to Methionine Ratios on Antioxidant Capacity and Immune Function in the Rumen of Tibetan Sheep: An RNA-Seq Analysis.

With global protein prices on the rise, lowering protein levels in animal feed, together with balancing diet composition and reducing nitrogen emissions, can both reduce the environmental impact of agriculture and save on feed costs. However, the formulation of an ideal amino acid (AA) composition is crucial for better protein utilization by livestock. This study aimed to investigate the effects of different lysine to methionine ratios on the antioxidant capacity and immune function of the rumen in Tibetan sheep.

Development and validation of non-invasive prediction models for assessing kidney histopathological activity index in lupus nephritis.

Objective: To develop and validate prediction models for estimating the activity index (AI) of kidney histopathology in lupus nephritis (LN) using clinical and laboratory data.

Methods: This study used single-center data from patients with kidney biopsy-confirmed LN between January 2012 and March 2022. The development and validation datasets were temporally cut.

Design and synthesis of JNK1-targeted PROTACs and research on the activity.

Kinase dysregulation is greatly associated with cell growth, proliferation, differentiation and apoptosis, which indicates their great potential as therapeutic targets for treatment of numerous progressive disorders, including inflammatory, metabolic and autoimmune disorders, organ fibrosis and cancer. The c‑Jun N‑Terminal Kinase (JNK), as a member of MAPK family, is proved to be a potential target for the treatment of pulmonary fibrosis, which is the most common progressive and fatal fibrotic lung disease. As a new strategy, small-molecule-mediated targeted protein degradation pathway has the advantages of catalytic properties, overcoming drug resistance and expanding target space, which can circumvent the limitations associated with kinase inhibitors.

Free-standing bimetallic Co/Ni-MOF foams toward enhanced methane dry reforming under non-thermal plasma catalysis.

Understanding of the structure and interfacial merits that reactive metal-organic frameworks (MOFs) undergo is critical for constructing efficient catalysts for non-thermal plasma-assisted conversion of greenhouse gases. Herein, we proposed a free-standing bimetallic (Co/Ni) MOFs supported on bacterial cellulose (BC) foams (Co/Ni-MOF@BC) toward the coaxial dielectric barrier discharge (DBD) plasma-catalytic system, of which the Co/Ni ions coordination demonstrated an intriguing textual uplifting of the malleable BC nanofiber network with abundant pores up to micrometer-scale, which could impart a more intensive predominant filamentary microdischarge current to 180 mA with stronger plasma-catalytic interaction. Remarkably, compared to the monometallic MOF@BC foams, this bimetallic Co/Ni-MOF@BC also delivered a substantially improved alkaline absorption ability as further confirmed by the CO- temperature-programmed desorption (TPD) result.