Hypoxia Promotes Osteoclast Differentiation by Weakening USP18-Mediated Suppression on the NF-κB Signaling Pathway.

Osteoporosis, a prevalent metabolic bone disorder, is characterized by reduced bone density and increased fracture risk. The pathogenesis of osteoporosis is closely associated with an imbalance in bone remodeling, in which the resorption function of osteoclasts exceeds the formation function of osteoblasts. Hypoxia has been implicated in the promotion of osteoclast differentiation and the subsequent development of osteoporosis.

First Report of Causing Rhizome Rot of Hua (Duohua Huangjing) in China.

Polygonatum cyrtonema Hua (Duohua Huangjing, Asparagaceae in angiosperms) is a traditional medicinal and edible plant in China. Its rhizomes can potentially enhance immunity, reduce tumor growth and the effects of aging, improve memory, and even reduce blood sugar levels (Zhao et al. 2020).

Comparing magnetic resonance enterography and endoscopy findings to the motility of magnetic resonance imaging in pediatric Crohn's disease.

Background: Quantitative magnetic resonance imaging (MRI) can evaluate bowel motility in children with Crohn's disease. As inflammation increases, motility decreases.

Objective: Our aim was to show that quantitative MRI correlates with magnetic resonance enterography (MRE).

Unraveling the Anthocyanin Regulatory Mechanisms of White Mutation in by Integrative Transcriptome and Metabolome Analysis.

: is a perennial herb of the Verbenaceae family, known for its medicinal properties, wide adaptability, and high resistance. : This research investigated the metabolic pathways of flower color change by combining transcriptome and metabolomics analyses. : In purple flowers and white variants, a total of 118 differentially accumulated metabolites (DAMs), including 20 anthocyanins, and 7627 differentially expressed genes (DEGs) were found.

Enterolactone combined with m6A Reader IGF2BP3 inhibits malignant angiogenesis and disease progression in ovarian cancer.

Background: Among all gynecological cancers, ovarian cancer is the leading cause of death. Epithelial ovarian cancer (EOC) accounts for over 85 % of ovarian cancer cases and is characterized by insidious onset, early metastasis, and a high recurrence rate. Alterations in gut microbiota, often as a consequence of chemotherapy, can promote cancer development and exacerbate the disease.