A vascular permeability factor in lymphocyte culture supernants from patients with nephrotic syndrome. II. Pharmacological and physicochemical properties.

Pharmacological properties of the "Skin Reactive Factor" demonstrated in nephrotic patients are similar to guinea-pig Skin Reactive Factor. This biological activity is not antagonized by anti-histaminic and anti-serotonin drugs. It is inhibited by meclofenamate and pyridinolcanbamate.

A vascular permeability factor elaborated from lymphocytes. I. Demonstration in patients with nephrotic syndrome.

P.H.A.

Lymphokine 'skin reactive factor' (SRF) and the nephrotic syndrome.

Lymphocytes from N.S. patients, in culture and stimulated by PHA or Con A, release a lymphokine which increases vascular permeability; this factor is not present in normal subject and in control supernatants.