OXCT1 succinylation and activation by SUCLA2 promotes ketolysis and liver tumor growth.

Ketone bodies generated in hepatocytes in the adult liver are used for nonhepatic tissues as an energy source. However, ketolysis is reactivated in hepatocellular carcinoma (HCC) cells with largely unelucidated mechanisms. Here, we demonstrate that 3-oxoacid CoA-transferase 1 (OXCT1), a rate-limiting enzyme in ketolysis, interacts with SUCLA2 upon IGF1 stimulation in HCC cells.

TTSNet: Transformer-Temporal Convolutional Network-Self-Attention with Feature Fusion for Prediction of Remaining Useful Life of Aircraft Engines.

Accurately predicting the remaining useful life (RUL) is crucial for ensuring the safety and reliability of aircraft engine operation. However, aircraft engines operate in harsh conditions, with the characteristics of high speed, high temperature, and high load, resulting in high-dimensional and noisy data. This makes feature extraction inadequate, leading to low accuracy in the prediction of the RUL of aircraft engines.

High-Coordination and Nb-Bridging of Bimetallic Amorphous P-Nb-W-P Clusters in Carbon Nanospheres for High-Performance Sodium-Ion Hybrid Capacitors.

Amorphous clusters are gaining prominence as prospective hosts for sodium-ion hybrid capacitors (SIHCs), but their efficacy is still affected by atomic coordination. Optimization of ion storage and charge transport can be achieved through high coordination and bimetallic configurations. Herein, high-coordination amorphous P-Nb-W-P (Nb/W-P) clusters are skillfully tailored by bridging Nb into the second shell of W in the W-P configuration, nested in situ in conductive and stable N, P co-doped carbon nanospheres (Nb/W-P@NPC).

Attitudes Toward General Vaccination Mediate the Association Between Influenza Vaccination History and Pneumococcal Vaccination Intention Among Older Adults in China.

Influenza and pneumococcal vaccinations play a crucial role in disease prevention among older adults and are recommended to older adults aged 60 years and over in China, but the vaccination rates are suboptimal. Behavioral spillover indicates that a change in one behavior may lead to changes in other related behaviors. Based on the Behavioral Spillover Theory, this study aimed to investigate the association between influenza vaccination history and pneumococcal vaccination intention, as well as the mediating role of negative attitudes toward general vaccination among older adults in China.

Genetic Variation for Wild Populations of the Rare and Endangered Plant Based on Double-Digest Restriction Site-Associated DNA Sequencing.

is an endangered tree species, and detecting its genetic diversity can reveal the mechanisms of endangerment, providing references for the conservation of genetic resources. Samples of 137 trees across seven populations within Fujian Province were collected and sequenced using double-digest restriction site-associated DNA (ddRAD-seq). A total of 3,687,189 single-nucleotide polymorphisms (SNPs) were identified, and 15,158 high-quality SNPs were obtained after filtering.