Differences of longitudinal plasma biomarkers between single memory domain and multidomain subject cognitive decline: Evidence from SILCODE.

Background: Plasma biomarkers demonstrated potential in identifying amyloid pathology in early Alzheimer's disease. Different subtypes of subjective cognitive decline (SCD) may lead to different cognitive impairment conversion risks.

Objective: To investigate the differences of plasma biomarkers in SCD subtypes individuals, which were unclear.

Advancing brain immunotherapy through functional nanomaterials.

Glioblastoma (GBM), a highly aggressive brain tumor, poses significant treatment challenges due to its highly immunosuppressive microenvironment and the brain immune privilege. Immunotherapy activating the immune system and T lymphocyte infiltration holds great promise against GBM. However, the brain's low immunogenicity and the difficulty of crossing the blood-brain barrier (BBB) hinder therapeutic efficacy.

Correlation between serum adenosine deaminase levels and risk of diabetic foot ulcers in patients with type 2 diabetes mellitus.

Objectives: Adenosine deaminase (ADA) is a critical enzyme in the catabolism of adenosine acid during purine metabolism and plays a significant role in the diagnosis and monitoring of various diseases. This study aims to investigate the relationship between serum ADA levels and risk of diabetic foot ulcers (DFU) in patients with type 2 diabetes mellitus (T2DM), providing a clinical basis for the prevention and treatment of DFU.

Methods: A retrospective study was conducted on 2 719 T2DM patients diagnosed at the Southwest Hospital of Army Medical University from January 2019 to January 2020.

Design, synthesis, and biological evaluation of N-(2-(adamantan-1-yl)-1H-indol-5-yl)-N-(substituent)-1,2-dicarboxamides as anticancer agents targeting Nur77-mediated endoplasmic reticulum stress.

Targeting endoplasmic reticulum (ER) stress-induced apoptosis has attracted considerable research interest in anti-cancer drug development. Nur77 is a potential therapeutic target in many cancers and several Nur77 modulators have recently been identified as effective anticancer agents by activating ER stress. As an ongoing work, this study reports a new series of novel N-(2-(adamantan-1-yl)-1H-indol-5-yl)-N-(substituent)-1,2-dicarboxamides as potent Nur77 modulators that cause ER stress-induced apoptosis.

Analysis of the structure and robustness of the global semiconductor trade network.

Amidst the global restructuring of the semiconductor supply chain, this paper constructs a global semiconductor trade network (2007, 2012, 2017, 2021) encompassing three segments (raw materials, equipment, and finished components), based on the CEPII database. After initially exploring trade flows among different regions, the paper conducts an in-depth analysis of the network's overall structure and the significance of its nodes. Furthermore, the evolution of the trade network's community structure is discussed and its robustness and dynamics over recent years are assessed through computer program simulation.