Publications by authors named "S Wrobel"
The German Environmental Specimen Bank (ESB) annually archives 24-h urine samples since the early 1980s. In this study, we analyzed 420 of these samples from the years 2014 to 2022 for metabolites of 18 phthalates and two substitutes. We merged the new data with the data from previous measurement campaigns to a combined dataset of 1825 samples covering a 35-year period from 1988 to 2022 to investigate time trends, calculate daily intakes and perform an anti-androgenic mixture risk assessment.
View Article and Find Full Text PDFAntibodies are a cornerstone of the immune system, playing a pivotal role in identifying and neutralizing infections caused by bacteria, viruses, and other pathogens. Understanding their structure, and function, can provide insights into both the body's natural defenses and the principles behind many therapeutic interventions, including vaccines and antibody-based drugs. The analysis and annotation of antibody sequences, including the identification of variable, diversity, joining, and constant genes, as well as the delineation of framework regions and complementarity-determining regions, is essential for understanding their structure and function.
View Article and Find Full Text PDFArticle Synopsis
- - Schistosomiasis, caused by parasitic worms, affects over 250 million people and primarily impacts the gastrointestinal tract, triggering a specific immune response linked to the formation of granulomas through its eggs.
- - A study on hamsters explored the connection between the number of parasitic eggs and the immune response, analyzing egg load and cytokine expression in liver and colon tissues.
- - Results showed no link between Th1 cytokines and egg load in the liver, while some Th2 cytokines exhibited an unexpected inverse correlation, potentially due to prolonged embryogenesis of eggs in the liver, which didn't occur in the colon.
Article Synopsis
- - This study focused on the bioavailability of omega-3 fatty acids, specifically comparing the effects of single doses of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on plasma levels in healthy men aged 20-40 with low fish consumption.
- - Twelve participants underwent a cross-over design, receiving either 2.2 g of EPA or 2.3 g of DHA, with blood samples collected at various intervals to track changes in plasma concentrations.
- - Results showed that EPA led to significantly higher plasma concentrations and a greater area under the concentration curve compared to DHA, indicating that EPA is more effective in raising plasma levels when administered in single doses.
Background: PRISMA-based literature reviews require meticulous scrutiny of extensive textual data by multiple reviewers, which is associated with considerable human effort.
Objective: To evaluate feasibility and reliability of using GPT-4 API as a complementary reviewer in systematic literature reviews based on the PRISMA framework.
Methodology: A systematic literature review on the role of natural language processing and Large Language Models (LLMs) in automatic patient-trial matching was conducted using human reviewers and an AI-based reviewer (GPT-4 API).