Publications by authors named "S Worthington"

Objectives: Self-domestication theory and preliminary data suggest that western chimpanzees (Pan troglodytes verus) could have smaller brains than eastern chimpanzees (P. t. schweinfurthii), but no large-scale studies of chimpanzee endocranial volume (ECV) have tested this.

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Article Synopsis
  • The study investigates the glycemic patterns in children with congenital hyperinsulinism (HI) using Continuous Glucose Monitoring (CGM) over a 12-month period to provide better insights for future treatments.
  • It involved 45 patients, revealing a consistent risk of hypoglycemia, especially early in the morning, but showed that CGM did not effectively reduce these episodes and the device's accuracy was found to be poor.
  • Despite high dissatisfaction among patients and families regarding CGM usage, qualitative feedback indicated that it helped them understand glycemic patterns and make behavior adjustments to reduce hypoglycemia.
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Introduction: Neonatal and early-life hypoglycaemia, is a frequent finding but is often non-specific and asymptomatic, making detection and diagnosis challenging. Hypoglycaemia-induced cerebral injury can be identified by magnetic resonance imaging (MRI) changes in cerebral white matter, occipital lobes, and posterior parietotemporal regions. It is unknown if children may have hypoglycaemic brain injury secondary to unrecognised hypoglycaemia in early life.

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Introduction: Patients with congenital hyperinsulinism (HI) require constant glucose monitoring to detect and treat recurrent and severe hypoglycemia. Historically, this has been achieved with intermittent self-monitoring blood glucose (SMBG), but patients are increasingly using continuous glucose monitoring (CGM). Given the rapidity of CGM device development, and increasing calls for CGM use from HI families, it is vital that new devices are evaluated early.

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