Publications by authors named "S Wist"

Article Synopsis
  • The study investigates the relationship between metabolic disorders and rotator cuff injuries, focusing on how different types of injuries (acute tears vs. chronic degeneration) affect tendon metabolite profiles.
  • Using untargeted metabolomics, researchers discovered that acute tears led to decreased levels of metabolites, particularly glycolic acid and TCA cycle activity, while chronic degeneration was associated with increased amino acids like alanine and proline.
  • The findings suggest that different injury types have unique metabolite profiles, highlighting the need for targeted therapeutic strategies that address both cellular and matrix changes in rotator cuff injuries.
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Background: Low load exercise training with blood flow restriction (BFR) has become increasingly used by human physical therapists to prescribe controlled exercise following orthopaedic injury; its effects on the equine superficial digital flexor tendon (SDFT), however, are unknown.

Objective: To investigate outcomes of pressure specific BFR walking exercise on uninjured equine SDFT biomechanics and histomorphology.

Study Design: Controlled in vivo experiment.

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The present work presents an algorithmic approach to determine the optimal starting point for any complex geometry draping processes. The time-efficient Kinematic Draping Simulation (KDS) is used to assess the drapability of a geometry depending on many different starting points. The optimization problem is then solved by applying Particle Swarm Optimization (PSO).

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Impaired mitochondrial function and disrupted proteostasis contribute to musculoskeletal dysfunction. However, few interventions simultaneously target these two drivers to prevent musculoskeletal decline. Nuclear factor erythroid 2-related factor 2 (Nrf2) activates a transcriptional programme promoting cytoprotection, metabolism, and proteostasis.

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Aim: The aim of this cross-sectional study was to measure the effect of dual tasks on gait stability in ambulant children with cerebral palsy (CP) compared to typically developing (TD) children.

Methods: The children of the CP (n = 20) and TD groups (n = 20) walked first without a dual task, then while counting forward and finally while alternatively naming fruits and animals (DTf/a). They then completed the same cognitive exercises while sitting comfortably.

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