Objective: Low fetal fraction (LFF) in prenatal cell-free DNA (cfDNA) testing is an important cause of test failure and no-call results. LFF might reflect early abnormal placentation and therefore be associated with adverse pregnancy outcome. Here, we review the available literature on the relationship between LFF in cfDNA testing and adverse pregnancy outcome.
View Article and Find Full Text PDFStudy Question: What are the pregnancy outcomes for women with a twin pregnancy that is reduced to a singleton pregnancy?
Summary Answer: Fetal reduction of a twin pregnancy significantly improves gestational age at birth and neonatal birthweight, however at an increased risk of pregnancy loss and preterm delivery.
What Is Known Already: Women with a multiple pregnancy are at increased risk for preterm delivery. Fetal reduction can be considered in these women.
Objective: The objective of the study was to assess in trichorionic triplet pregnancies the effectiveness of elective reduction to twins.
Study Design: This was a nationwide retrospective cohort study. We compared the time to delivery and perinatal mortality in trichorionic triplet pregnancies electively reduced to twins with ongoing trichorionic triplets and primary dichorionic twins.
Eur J Obstet Gynecol Reprod Biol
July 2013
Objective: To determine and compare the diagnostic accuracy of the lecithin/sphingomyelin (L/S) ratio and lamellar body count (LBC) in the prediction of neonatal respiratory distress syndrome (RDS).
Study Design: A systematic review was performed to identify studies comparing either the L/S ratio or the LBC with the occurrence of RDS published between January 1999 and February 2009. Two independent reviewers performed study selection and data extraction.