Current treatment of systemic lupus erythematosus: a clinician's perspective.

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease. Its variable course makes it difficult to standardize patient treatment. This article aims at a literature review on available drugs for treating SLE and on drugs that have shown therapeutic effects in this disease.

Working toward sustainability: Transitioning HIV programs from a USA-based organization to a local partner in Zimbabwe.

Background: Despite the history of United States of America (USA)-based partners implementing global health programs in low- and middle-income countries (LMIC), future models for sustainable healthcare rely on local country ownership and leadership. Transition is the process of shifting programs towards country ownership, where local stakeholders plan, manage, and deliver health programs. Transition is not a singular event but a process which may include a phase where health programs are led and managed by local entities but still reliant on awards from international partners.

Affinity-based proteomics reveals novel binding partners for Rab46 in endothelial cells.

Rab46 is a novel Ca-sensing Rab GTPase shown to have important functions in endothelial and immune cells. The presence of functional Ca-binding, coiled-coil and Rab domains suggest that Rab46 will be important for coupling rapid responses to signalling in many cell types. The molecular mechanisms underlying Rab46 function are currently unknown.

The rollout of Community ART Refill Groups in Zimbabwe: a qualitative evaluation.

Introduction: Community ART Refill Groups (CARGs) are an antiretroviral therapy (ART) delivery model where clients voluntarily form into groups, and a group member visits the clinic to collect ART for all group members. In late 2016, Zimbabwe began a nationwide rollout of the CARG model. We conducted a qualitative evaluation to assess the perceived effects of this new national service delivery model.