Publications by authors named "S Widjaja"
Central Retinal Artery Occlusion (CRAO) is a serious ophthalmic emergency characterized by sudden, painless vision loss in one eye. This condition leads to rapid and significant visual impairment if not treated promptly. This case illustrates an adult man with hypertension presented with unilateral, painless, sudden vision loss occurring 13 hours before admission.
View Article and Find Full Text PDFIndividuals with human immunodeficiency virus (HIV) infection are prone to developing persistent and unremitting anogenital warts (AGWs). To address this health condition, immunotherapy using tuberculin purified protein derivative (PPD) has been proven to be a promising novel and safe treatment for AGWs in HIV patients. Therefore, this study involved a case of a 21-year-old man with stage I HIV infection, possessing CD4 counts 548 cells/uL and routinely receiving HIV antiretroviral.
View Article and Find Full Text PDFAcute pain, moderate-to-severe cancer pain, and persistent malignant pain are all frequently treated with opioids. It is regarded as one of the main tenets of analgesic treatment. The relationship between human opioid sensitivity and genetic polymorphism differences has received little attention up to this point in research.
View Article and Find Full Text PDFBackground: Cell aging is associated with changes in telomeres due to DNA damage arising from chronic inflammation in obese patients. The aim of the systematic review and meta-analysis was to find the relationship between obesity and aging or senescence.
Methods: The systematic review was conducted through PRISMA guideline, beginning with literature search within 2012-2022 in several databases (PubMed, EBSCOHost, Science Direct, Scopus, and Cochrane) followed by screening process using predetermined PICO criteria.
Article Synopsis
- Ageing significantly increases the risk of non-communicable diseases, which include cognitive, metabolic, and cardiovascular issues, largely due to mitochondrial dysfunction and oxidative stress.
- PGC-1α is a key transcriptional coactivator that enhances mitochondrial function and is influenced by factors like dietary restriction, which has been linked to increased PGC-1α expression in tissues.
- Research suggests that dietary interventions can promote mitochondrial health, potentially delaying the ageing process and reducing the occurrence of age-related diseases.