Letters to the editor: Nicotinic acetylcholine receptor ligands as potential targets for managing neuropathic pain induced by diabetic peripheral neuropathy.

Diabetic peripheral neuropathy (DPN) is a medical condition that is progressively becoming more prevalent. The underlying cause of DPN is still unknown, although there have been several hypothesized mechanisms. There are current pharmaceutical treatments used to manage the pain, but their efficacy is largely unsatisfactory and are often associated with serious adverse effects.

Building the BBC-branded NGO: Overseas Development, the World Service, and the Marshall Plan of the Mind, c.1965-99.

Overseas broadcasting has been an integral part of the BBC's remit since the creation of its Empire Service in 1932. Throughout its history, the BBC has consistently argued that its services for overseas listeners should not be classified as a form of British propaganda, but instead understood as a fundamentally benevolent undertaking, providing objective, impartial, and trustworthy news and information to hundreds of millions of listeners worldwide. In the post-imperial era, the World Service increasingly depicted itself as not just a 'global public service broadcaster', but also as a kind of humanitarian endeavour, an 'Oxfam of the Mind' which made a significant contribution to Britain's wider efforts in the field of overseas development.

Tumour necrosis factor antagonists and the risk of cardiovascular disease in patients with rheumatoid arthritis: a systematic literature review.

Objectives: RA is associated with early ischaemic heart disease. This appears to be driven largely by the presence of chronic inflammation. Studies suggest that treatment with disease-modifying drugs such as MTX may reduce the incidence of cardiovascular events in RA.