Different patterns of serum interleukin 10 response to treatment with anti-tumor necrosis factor alpha antibody (infliximab) in Crohn's disease.

Administration of anti-tumor necrosis factor antibody (anti-TNF, infliximab) down-regulates T helper 1 (Th 1) cytokines production in intestinal mucosa of patients with Crohn's disease (CD). Interleukin 10 (IL-10) is thought to be involved in CD pathogenesis through regulation of the Th 1 response. The aim of this study was to determine the IL-10 response in CD patients treated with anti-TNF.

Levels of coenzyme Q10 in asthmatics.

Background: The contribution of free oxygen radicals in the pathogenesis of bronchial asthma is generally accepted. The modulation of antioxidative defence by supplementation with antioxidants represents additive approach in complex management of the disease. The aim of the study was to assess the levels of coenzyme Q10, alpha-tocopherol, beta-carotene and malondialdehyde (end-stage parameter of lipid peroxidation) in asthmatics (As).

Effects of occupational exposure to styrene on expression of adhesion molecule on leukocytes.

Styrene is an indispensable chemical extensively used in plastic and synthetic rubber industries. Styrene is known to produce various types of hepatotoxic, neurotoxic, and genotoxic effects. Styrene may be immunotoxic by both direct and indirect mechanisms.

Effects of selenium supplementation on expression of adhesion molecules in corticoid-dependent asthmatics.

Selenium (Se) deficiency attenuates the host immune response, thereby increasing the risk of bacterial and viral infections. We have examined the effects of selenium supplementation (SeS) in corticoid-dependent asthmatics (CDAs) with lowered circulatory Se status. Twenty CDAs (10 males and 10 females, average age 54.

Inflammatory mechanisms involving neutrophils in chronic venous insufficiency of lower limbs.

Background: It is supposed that an inflammatory reaction is one of the major factors responsible for the chronic venous insufficiency (CVI) of lower limbs which cause leg ulcers.

Objectives: The main objective of the present study was to determine the differences in the levels of typical inflammatory mediators and markers produced by neutrophils of patients with CVI and normal control subjects.

Subjects And Methods: 26 patients with CVI and 39 clinically healthy subjects were included in the study.