Publications by authors named "S Weidemann"
Background: Claudin-3 (CLDN3) participates in the formation of the tight-junctions (TJs) that regulate intercellular permeability. Altered CLDN3 expression has been linked to tumor progression in multiple tumor types. Despite its widespread expression in normal epithelial cells, CLDN3 is considered an attractive drug target candidate, since it may be more accessible in cancer cells than in normal cells due to their less orchestrated cell growth.
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- Accurate diagnosis in psychiatry is challenging, leading to delays in treatment and worse outcomes; identifying biomarkers for emotional reactivity is key.
- The study evaluated emotional responses of individuals with bipolar disorder (BD), borderline personality disorder (BPD), schizophrenia spectrum disorders (SSD), and healthy controls (HC) in immersive virtual reality (VR) scenarios, measuring self-rated emotions and galvanic skin response (GSR).
- Results showed that individuals with BD, BPD, and SSD had more negative emotional responses than HC, with BPD and SSD experiencing heightened unpleasantness and stronger physiological responses in specific VR contexts, suggesting VR assessments could enhance diagnosis and treatment strategies.
PAX6 immunohistochemistry (IHC) was proposed as a tool to identify a pancreatic origin of neuroendocrine neoplasms (NENs). To evaluate the diagnostic utility of PAX6 IHC, a tissue microarray containing 19,214 samples from 150 tumor types was analyzed. Data on progesterone receptor (PR) and glutamate decarboxylase 2 (GAD2) expression were available from previous studies.
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- Anterior gradient 2 (AGR2) is a key protein involved in various biological processes like embryonic development, tissue regeneration, and wound healing, with potential implications in cancer research.
- A comprehensive analysis of nearly 15,000 tumors and normal tissue samples revealed that AGR2 expression is present in a majority of tumor categories, particularly in tumors of the female genital tract and various adenocarcinomas.
- High levels of AGR2 are associated with poor clinical outcomes in several cancer types, suggesting its role as a potential biomarker for tumor aggressiveness and progression.
The protein gene product 9.5 (PGP9.5), also termed ubiquitin C-terminal hydrolase L1 (UCH-L1) is an important component of the ubiquitination/deubiquitination system and plays a role in axonal transport.
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