Publications by authors named "S Wahab"
Committed to our growing effort addressed toward the development of potent anti-breast cancer candidates, new 4-hydrazinylpyrimidine-5-carbonitriles featuring a morpholinyl or piperidinyl moiety at the position-2 and derivatized with various functionalities at the hydrazinyl group were designed through structure optimization, and their antiproliferative potency against two human breast cancer (BC) cell lines, relative to the reference drug 5-FU, was evaluated. Compounds showing remarkable cytotoxic activity versus the hormone dependent MCF-7 cell line (IC = 1.62 ± 0.
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- The treatment of cancer has become more complex, utilizing traditional methods like chemotherapy and surgery, but innovative approaches are emerging, particularly involving folic acid-conjugated metal-based nanoparticles (NP) for targeted therapies, specifically photodynamic therapy (PDT) and photothermal therapy (PTT).
- These nanoparticles leverage the affinity of folic acid for folate receptors, which many cancer cells produce in excess, allowing for more precise and effective treatment delivery.
- The review highlights how these FA-functionalized metal nanoparticles enhance the effectiveness of PDT and PTT in lab and animal models, while also addressing challenges and future directions for their clinical application.
Mapping the Landscape of Trauma-Informed Care in Social Work: A Critical Scoping Review.
Trauma Violence Abuse
October 2024
Article Synopsis
- Trauma-informed care (TIC) has become increasingly important in social work despite limited empirical evidence supporting its effectiveness, prompting a review of its theoretical foundations and practical applications.
- The review analyzed 131 relevant peer-reviewed articles from 2012 to 2022, highlighting a broad, often individual-focused understanding of trauma, while largely overlooking institutional or structural aspects.
- The findings reveal a lack of clarity in TIC's practical application and raise concerns about its reliance on perceived trauma prevalence rather than strong research, suggesting a need for critical reassessment for better practice and research directions.
VEGFR2 inhibition has been established as a therapeutic approach for managing cancer. A series of curcumin-based analogues were designed, synthesized, and screened for their anticancer activity against MCF-7 and HepG-2 cell lines and WISH normal cells. Compounds 4b, 4d, 4e, and 4f showed potent cytotoxicity against MCF-7 with IC values of 0.
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- - The study focuses on developing a valid and reliable Knowledge, Attitude, and Practices (KAP) questionnaire specifically about methamphetamine use among Malaysian adolescents due to rising usage trends and public health concerns.
- - Through extensive validation processes, including input from various stakeholders and pilot testing, the questionnaire demonstrated strong reliability and validity metrics, making it an effective tool for assessing awareness and behaviors related to methamphetamine use.
- - The findings from the questionnaire can not only serve as a valuable resource for understanding adolescent behaviors regarding methamphetamine but also guide the development of future intervention strategies aimed at addressing methamphetamine use disorders in youths.