Publications by authors named "S Waguri"
Background: γ1-Adaptin is a subunit of adaptor protein complex-1 (AP-1), which regulates intracellular transport between the trans-Golgi network (TGN) and endosomes. Since expression levels of AP-1 subunits have been reported to be associated with cell proliferation and cancer malignancy, we investigated the relationships between the immunohistochemical expression of γ1-adaptin and both clinicopathological factors and relapse-free survival (RFS) in breast cancer tissue.
Materials And Methods: SK-BR-3 cell line depleted of γ1-adaptin was used for cell proliferation, migration, and invasion assay.
infection can be regulated by autophagy-related () genes. Here, we found that the depletion of , one of the core genes, in HeLa cells suppressed growth in the inclusion. The growth was restored by re-expressing or an mutant impairing lipid scramblase activity in -knockout (KO) cells.
View Article and Find Full Text PDFNRF2 is a transcription factor responsible for antioxidant stress responses that is usually regulated in a redox-dependent manner. p62 bodies formed by liquid-liquid phase separation contain Ser349-phosphorylated p62, which participates in the redox-independent activation of NRF2. However, the regulatory mechanism and physiological significance of p62 phosphorylation remain unclear.
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- Autophagy plays a key role in regulating the degradation of specific biomolecular structures, such as p62/SQSTM1 bodies, to prevent diseases like cancer.
- Researchers developed a new method to purify and analyze the components of p62 bodies in human cells, revealing that a complex called vault is involved in this process.
- The study identifies a mechanism called vault-phagy, where major vault protein interacts with NBR1 to facilitate the degradation of vaults, and suggests that disruptions in this process may link to certain liver cancers.
Background: The Great East Japan Earthquake and the resulting tsunami and nuclear disaster on March 11, 2011 have had a profound and lasting effect on residents of Japan's Fukushima Prefecture, particularly among evacuees. While there continues to be extensive news coverage and academic study of Fukushima Prefecture's recovery, there has been little exploration of individual narratives. This study aims to illuminate some individual stories of medical students at Fukushima Medical University (FMU) who lived in the Prefecture at the time of the Earthquake.
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