Publications by authors named "S Wagenpfeil"
Background/aim: Solar ultraviolet radiation represents the most important environmental risk factor for skin cancer. However, vitamin D synthesis from sun exposure has been reported to exert anti-carcinogenic effects on melanocytes in vitro. This justifies the ongoing debate whether vitamin D status can be considered a risk and prognostic for primary cutaneous malignant melanoma.
View Article and Find Full Text PDFObjective: This study aimed to identify parameters that allow the estimation of tumor-infiltrated lymph nodes (LN) after pretreatment for unilateral Wilms tumor (WT).
Summary Background Data: Complete tumor resection with removal of regional LN is always necessary. Positive LNs require local irradiation influencing benefits in case of NSS in long-term follow-up.
Background: Vitamin A plays a key role in lung development, but there is no consensus regarding the optimal vitamin A dose and administration route in extremely low birthweight (ELBW) infants. We aimed to assess whether early postnatal additional high-dose fat-soluble enteral vitamin A supplementation versus placebo would lower the rate of moderate or severe bronchopulmonary dysplasia or death in ELBW infants receiving recommended basic enteral vitamin A supplementation.
Methods: This prospective, multicentre, randomised, parallel-group, double-blind, placebo-controlled, investigator-initiated phase 3 trial conducted at 29 neonatal intensive care units in Austria and Germany assessed early high-dose enteral vitamin A supplementation (5000 international units [IU]/kg per day) or placebo (peanut oil) for 28 days in ELBW infants.
Article Synopsis
- The study investigates mortality trends in congenital heart defects (CHD) in Germany over a 21-year period from 1998 to 2018, revealing a total of 11,314 deaths, mainly in infants and neonates.
- It notes a significant decline in mortality rates from 1998 to 2010, followed by a rise in the last three years, particularly affecting high-risk neonate and infant populations.
- The findings underline the need for better data collection on CHD-related deaths and the factors influencing these mortality trends to enhance patient outcomes.
Article Synopsis
- It's really important to tell different types of kidney tumors apart in kids because treatments start without needing a tissue sample.
- Researchers looked at details like age, tumor size, and whether tumors had spread in over 3000 kids with different kidney tumors to improve how doctors identify them.
- They found that different tumors appeared in kids at different ages and sizes, and two specific types (MRTK and RCC) were linked to a higher chance of spreading, showing that understanding these details can help doctors treat kids better!