BMJ Open
December 2024
Introduction: Fear of recurrence is a transdiagnostic problem experienced by people with psychosis, which is associated with anxiety, depression and risk of future relapse events. Despite this, there is a lack of available psychological interventions for fear of recurrence, and psychological therapies for schizophrenia are often poorly implemented in general. However, low-intensity psychological therapy is available for people who experience fear of recurrence in the context of cancer, which means there is an opportunity to learn what has worked in a well-implemented psychological therapy to see if any learning can be adapted for schizophrenia care.
View Article and Find Full Text PDFMicrobial source tracking (MST) is a critical tool for identifying sources of human and animal fecal pollution in aquatic environments. To enhance human fecal pollution tracking, this study evaluated the performance characteristics of pBI143, a cryptic plasmid recently identified for potential MST applications. Nucleic acid samples from ten animal species were screened for pBI143, revealing its presence in a small number of pigs, cows, dogs, cats, and flying fox fecal samples.
View Article and Find Full Text PDFBackground: This study examined the association between opioid-use disorder (OUD)-related diagnoses (eg, opioid dependence) and social determinants of health (SDoH) among patients with chronic pain.
Methods: A cross-sectional study was performed using the All of Us dataset (including >70,000 patients) to measure associations between SDoH and OUD using population- and individual-level surveys. Mixed-effects multivariable regression models (random effect being zip code) were conducted for each of the key SDoH domains.
Aims: Several methods are available to help identify people with depression; however, there is little guidance on when to start screening. This study estimated the incidence of new depressive episodes and identified factors associated with onset in adults with newly treated type 2 diabetes.
Methods: Administrative health data from Alberta, Canada was used to identify people starting metformin between April 2011 and March 2015.
Artificial light at night (ALAN) is an anthropogenic pollutant that is intensifying and expanding in marine environments, but experimental studies of community-level effects are generally lacking. The inshore, shallow, and clear-water locations of coral reefs and their diverse photosensitive inhabitants make these ecosystems highly susceptible to biological disturbances; at the same time, their biodiversity and accessibility make them model systems for wider insight. Here, we experimentally manipulated ALAN using underwater LED lights on a Polynesian reef system to investigate the influence on localised nighttime fish communities compared to control sites without ALAN.
View Article and Find Full Text PDF