Enhanced pathogen identification among patients with clinically suspected meningitis.

Background: Delayed or incorrect treatment of meningitis may result in adverse patient outcomes. However, laboratory testing in resource-limited settings is often limited to conventional diagnostic methods. We explored the utility of syndromic molecular assays for diagnosis.

Evaluating the genetic components of growth in ostriches with multi-trait and random regression models.

1. The heritability (h) of liveweight (LW) in ostriches can be highly variable, depending on age at recording. The objective of this study was to consider random regression (RR) as an alternative to the multi-trait (MT) structure for the analysis of repeated measures of LW.

Synthesis of 1,2,4-Oxadiazin-5(6)-One Derivatives and Their Biological Investigation as Monoamine Oxidase Inhibitors.

Monoamine oxidase (MAO) plays a key role in the pathogenesis of central nervous system disorders, and MAO inhibitors have been used in the treatment of depression and Parkinson's disease. In the search for new classes of MAO inhibitors, the present study investigated a series of 1,2,4-oxadiazin-5(6)-one derivatives. This study provides the first optimization of the reaction conditions for the condensation of amidoximes with alkyl 2-halocarboxylates to yield the desired 1,2,4-oxadiazin-5(6)-ones.

Estimation of breed effects and non-additive genetic variation for ostrich slaughter and skin traits.

The study quantified breed effects and putative non-additive genetic variation for quantitative and qualitative slaughter and skin traits involving three ostrich breeds: South African Black (SAB), Zimbabwean Blue (ZB), and Kenyan Red (KR) ostriches. Such data from contemporary slaughter groups with all three pure breeds represented were analyzed together (SAB: n = 457; ZB: n = 74; KR: n = 50). Two 2 × 2 diallel crossbreeding designs were used to assess crosses of ZB and KR birds with the SAB strain.

Genetic parameters and correlations for behavioural response traits towards humans in South African Black ostriches.

1. The aim of this study was to estimate heritability and genetic correlations, first among behavioural responses of juvenile South African Black ostriches towards humans and secondly with slaughter weight and skin traits.2.