Characterising the blood-stage antimalarial activity of pyronaridine in healthy volunteers experimentally infected with Plasmodium falciparum.

With the spread of artemisinin resistance throughout Southeast Asia and now in Africa, the antimalarial drug pyronaridine is likely to become an increasingly important component of new antimalarial drug regimens. However, the antimalarial activity of pyronaridine in humans has not been completely characterised. This volunteer infection study aimed to determine the pharmacokinetic/pharmacodynamic (PK/PD) relationship of pyronaridine in malaria naïve adults.

Reversal learning after prenatal or early postnatal alcohol exposure in juvenile and adult rats.

Learning tasks that require the reversal of a previously learned contingency are disrupted in animals and humans exposed to alcohol during the perinatal period. The current experiments examined how varying the time of alcohol exposure and the age at which subjects were tested would affect the expression of reversal deficits in a T-maze task. Groups of rats were exposed to alcohol from gestational day (GD) 8 to GD20 or from postnatal day (PN) 4 to PN9, and then tested in a spatial reversal task at either PN28 or PN63.

Anal canal strictures after ileal pouch-anal anastomosis.

Purpose: This study was designed to define the different types of strictures, the factors favoring their occurrence, and their treatment after ileal pouch-anal anastomosis.

Methods: Between January 1981 and June 1996, 1,884 ileal pouch-anal anastomoses were constructed at the Mayo Clinic in Rochester, Minnesota. Data were collected prospectively and included age, gender, type of underlying diseases (chronic ulcerative colitis familial adenomatous polyposis), proctologic antecedents, technique of anastomosis, intraoperative difficulties, and postsurgical complications.

Improving measurement stability and reproducibility of potentiometric sensors for polyions such as heparin.

The growing importance of polymer membrane-based potentiometric polyion sensors in biomedical research and clinical measurements has brought up the question of how accurate and reproducible these sensors are. Indeed, recent research has revealed that these sensors behave quite differently than classical ion-selective electrodes. This paper explores ways to improve measurement reproducibility and long term potential stability by considering the unique pseudo steady-state response mechanism of the polyion sensors developed so far.

Renewable pH cross-sensitive potentiometric heparin sensors with incorporated electrically charged H+ ionophores.

Polymer membrane-based potentiometric sensors have been developed earlier to provide a rapid and direct method of analysis for polyions such as heparin, a natural anticoagulant administered to prevent thrombus formation during cardiovascular surgery. These heparin sensors are irreversible, requiring a membrane renewal procedure between measurements which currently prevents the sensors from being used for continuous monitoring of blood heparin. A newly developed heparin sensor is shown here to allow an alternate and more practical method of membrane renewal.