Publications by authors named "S W Maley"
Article Synopsis
- Understanding the relationship between breast cancer and its microenvironment is crucial for improving treatment and outcomes.
- Researchers identified two distinct transcriptomic subtypes and five immune infiltration patterns in a study of 21 estrogen receptor-positive (ER+) and HER2-negative invasive lobular carcinomas (ILCs).
- A notable finding was that a proliferative subtype had higher levels of suppressive immune cells, while a specific gene signature linked to lower proliferation and more pro-inflammatory tumor-associated macrophages indicated better survival rates in ER+ breast cancer patients.
Understanding interplay of breast cancer and microenvironment is critical. Here, we identified two transcriptomic subtypes and five immune infiltration patterns from RNA-seq and multiplex immunohistochemistry from 21 ER+/HER2- invasive lobular breast cancers. The proliferative subtype associated with increased immune infiltration especially by immunosuppressive regulatory T-cells and macrophages.
View Article and Find Full Text PDFHemangiopericytoma is a rare vascular neoplasm derived from pericytes, with uncertain malignant potential. It mainly occurs in the retroperitoneum and lower extremities, with a lower incidence in the head and neck region and nasal cavity. Diagnosis is aided by histopathological examination and immunohistochemistry.
View Article and Find Full Text PDFBackground: We previously reported our phase Ib trial, testing the safety, tolerability, and efficacy of T-DM1 + neratinib in HER2-positive metastatic breast cancer patients. Patients with ERBB2 amplification in ctDNA had deeper and more durable responses. This study extends these observations with in-depth analysis of molecular markers and mechanisms of resistance in additional patients.
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