Cardiorespiratory Dynamics in the Brain: Review on the Significance of Cardiovascular and Respiratory Correlates in functional MRI signal.

Cardiorespiratory signals have long been treated as "noise" in functional magnetic resonance imaging (fMRI) research, with the goal of minimizing their impact to isolate neural activity. However, there is a growing recognition that these signals, once seen as confounding variables, provide valuable insights into brain function and overall health. This shift reflects the dynamic interaction between the cardiovascular, respiratory, and neural systems, which together support brain activity.

BioBERT based text mining for incorporating prior knowledge in the inference of genetic network models.

Reconstruction of Gene Regulatory Networks (GRNs) is essential for understanding gene interactions, their impact on cellular processes, and manifestation of diseases, including drug discovery. Among various mathematical and dynamic models used for GRN reconstruction, S-system model, comprising non-linear differential equations, is widely utilised to capture the behaviour of complex biological systems with non-linear and time-dependent interactions. However, as the network size increases, computational demand for network inference grows due to a greater number of estimation parameters, significantly impacting the performance of optimisation algorithms.

Clinical Manifestations.

Background: Research on hemodynamic responses in the prefrontal cortex during working memory tasks has mainly been performed in cognitive neuroscience research. However, the specific stimuli contributing to working memory deficits in major depressive disorder (MDD) are currently lacking. This study aims to compare working memory performance and prefrontal cortex activation in individuals with MDD and healthy controls during working memory tasks involving textual, visual, and emotional stimuli.

Bevacizumab exerts dose-dependent risk for intracranial hemorrhage in patients with malignant gliomas.

Purpose: Bevacizumab, an anti-VEGF monoclonal antibody, has become a mainstay therapeutic in the management of malignant glioma. It is unknown if the risk of intracranial hemorrhage (ICH), a major complication associated with bevacizumab use, is dose-dependent.

Methods: This was a single institution retrospective analysis of patients treated with bevacizumab for the management of gliomas between 2009 and 2022.