Publications by authors named "S W Leslie"
Background: The investigation of digital information sources and technologies specifically used by men with prostate cancer is scarce. This study seeks to address current gaps in the literature by investigating prostate cancer-specific internet and technology use by men with prostate cancer and factors associated with this use.
Methods: Cross-sectional surveys were conducted in three Australian urology clinics (local in Sydney, Western Sydney and Murrumbidgee) in 2023.
Article Synopsis
- HFpEF makes up about 50% of heart failure cases globally, increasing due to longer lifespans and more health issues.
- Wnt signaling is linked to heart problems like cardiomyocyte hypertrophy and fibrosis, and PORCN inhibitors (like Wnt-c59) show promise in improving heart function.
- In a study, Wnt-c59 reduced adverse heart changes and improved heart function in mice with HFpEF, even though Wnt signaling itself wasn't activated in their hearts.
Autosomal Dominant Polycystic Kidney Disease (ADPKD) results in progressive cysts that lead to kidney failure, and is caused by heterozygous germline variants in PKD1 or PKD2. Cyst pathogenesis is not definitively understood. Somatic second-hit mutations have been implicated in cyst pathogenesis, though technical sequencing challenges have limited investigation.
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