Palliative care needs in cystic fibrosis: hospital survey.

Background: Cystic fibrosis (CF) is an incurable, progressive disease that affects multiple organs, causing burdensome symptoms. This study aimed to explore the palliative care needs in patients with CF, focusing on health-related quality of life (HRQOL), fatigue, anxiety and depression.

Methods: From October 2019 to March 2020, a cross-sectional questionnaire survey was conducted with outpatients with CF at the Infectious Medicine Clinic in a Danish University Hospital.

Enrichment of Cancer-Associated Fibroblasts, Macrophages, and Up-Regulated TNF-α Signaling in the Tumor Microenvironment of CMS4 Colorectal Peritoneal Metastasis.

Background: Metastatic colorectal cancer (mCRC) is the main cause of CRC mortality, with limited treatment options. Although immunotherapy has benefited some cancer patients, mCRC typically lacks the molecular features that respond to this treatment. However, recent studies indicate that the immune microenvironment of mCRC may be modified to enhance the effect of immune checkpoint inhibitors.

Modelling and set-point definition for the development of a joint control system of two interconnected wastewater treatment plants and its application in practice.

The use of activated sludge models (ASMs) is a common way in the field of wastewater engineering in terms of plant design, development, optimization, and testing of stand-alone treatment plants. The focus of this study was the development of a joint control system (JCS) for a municipal wastewater treatment plant (mWWTP) and an upstream industrial wastewater treatment plant (iWWTP) to create synergies for saving aeration energy. Therefore, an ASM3 + BioP model of the mWWTP was developed to test different scenarios and to find the best set-points for the novel JCS.

Understanding the development of tuberculous granulomas: insights into host protection and pathogenesis, a review in humans and animals.

Granulomas, organized aggregates of immune cells which form in response to (), are characteristic but not exclusive of tuberculosis (TB). Despite existing investigations on TB granulomas, the determinants that differentiate host-protective granulomas from granulomas that contribute to TB pathogenesis are often disputed. Thus, the goal of this narrative review is to help clarify the existing literature on such determinants.

A Biomechanical Comparison Between Conventional, Sumo, and Hex-Bar Deadlifts Among Resistance Trained Women.

Gundersen, AH, van den Tillaar, R, Falch, HN, Fredriksen, AB, and Larsen, S. A biomechanical comparison between conventional, sumo, and hex-bar deadlifts among resistance trained women. J Strength Cond Res XX(X): 000-000, 2024-The deadlift is a multijoint exercise frequently used to strengthen the lower extremities and spinal erectors.