Publications by authors named "S W J Santana"
Conventionally, the size, shape, and biomechanics of cartilages are determined by their voluminous extracellular matrix. By contrast, we found that multiple murine cartilages consist of lipid-filled cells called lipochondrocytes. Despite resembling adipocytes, lipochondrocytes were molecularly distinct and produced lipids exclusively through de novo lipogenesis.
View Article and Find Full Text PDFPreclinical and/or clinical studies have demonstrated the potential of Ivermectin (IVM) for malaria control. In order to improve its antiplasmodial activity and build on previous knowledge, we have designed a third generation of hybrid molecules in which selected pharmacophores were appended to the IVM macrolide, while retaining one or both sugar moieties at the C-13 position. Moreover, we synthesized IVM hybrids that contain structural features of potent IVM metabolites.
View Article and Find Full Text PDFArticle Synopsis
- Agricultural pests directly harm crops and can also indirectly damage them by spreading harmful pathogens, affecting crop yield and quality.
- Mites, especially the two-spotted spider mite, are a significant concern in agriculture due to their widespread infestation of numerous plant species and potential contributions to agricultural losses.
- The study aimed to explore the virome of these mites using RNA sequencing, uncovering 20 viral sequences, including new and related strains that could impact food security and complicate pest management strategies.
Background: Hypovitaminosis D may be common in tropical countries and is linked to disorders of phospho-calcium metabolism, rickets, muscle pain, immune system deficiencies, and increased susceptibility to microbial infections.
Objective: To assess the prevalence of hypovitaminosis D in apparently healthy university workers in Loja, Ecuador.
Methods: A cross-sectional study was completed in a private Ecuadorian university from May 2023 to September 2023, involving 440 participants.
Effects of osteopathic manipulative treatment associated with transcranial direct current stimulation in individuals with chronic low back pain: A double-blind, randomised placebo-controlled trial.
Clin Rehabil
December 2024
Objective: To evaluate the effectiveness of osteopathic manipulative treatment (OMT) associated with transcranial direct current stimulation (tDCS) in reducing pain, disability, and improving quality of life in participants with non-specific chronic low back pain.
Design: A randomised double-blind clinical trial.
Setting: Clinical outpatient unit.