The brain interactome of a permissive prion replication substrate.

Bank voles are susceptible to prion strains from many different species, yet the molecular mechanisms underlying the ability of bank vole prion protein (BVPrP) to function as a universal prion acceptor remain unclear. Potential differences in molecular environments and protein interaction networks on the cell surface of brain cells may contribute to BVPrP's unusual behavior. To test this hypothesis, we generated knock-in mice that express physiological levels of BVPrP (M109 isoform) and employed mass spectrometry to compare the interactomes of mouse (Mo) PrP and BVPrP following mild in vivo crosslinking of brain tissue.

Patient digital self-screening tool for familial hypercholesterolaemia: A pilot study.

Background And Objectives: Familial hypercholesterolaemia (FH) is a genetic condition contributing to premature cardiovascular disease. Currently, general practitioners (GPs) do not proactively screen for the condition. This study implemented and evaluated a digital FH self-screening questionnaire administered in general practice.

Coptisine enhances the sensitivity of chemoresistant breast cancer cells by inhibiting the function and expression of ABC transporters.

Background: Multidrug resistance (MDR), mainly caused by ATP-binding cassette transporters (ABCTs) efflux, makes it difficult for many anticancer drugs to treat breast cancer (BC). Phytochemicals can reverse cancer's MDR by modifying ABC transporter expression and function, as well as working synergistically with anticancer drugs to target other molecules. The reversal effect of the isoquinoline alkaloid coptisine (COP) was assessed on four breast cell lines; Two sensitive MCF-7 cell lines with positive estrogen, androgen, progesterone, and glucocorticoid receptors, as well as MDB-MB-231 cells with negative estrogen, progesterone, and HER2 receptors, and two doxorubicin-resistant cell lines, MCF-7/ADR and MDB-MB-231/ADR.

Effects of a Telenutrition Weight Loss Program Supported with Telemonitoring and Telehealth Coaching on Anthropometric and Biochemical Measures in Overweight and Obese Adults: A Pilot Randomized Controlled Trial.

Background/objectives: Telenutrition has been reported to enable dietitians to support outpatients remotely in an accessible and convenient state. The literature shows that both telemonitoring and health coaching are effective approaches for achieving a greater impact on weight loss and the client's compliance with their diet. The purpose of the present study was to assess the impact of a telenutrition weight loss program on weight reduction, supported with telemonitoring and health coaching.