Publications by authors named "S W Dihlmann"
There is currently no clinically valid biomarker for predicting the growth and prognosis of abdominal aortic aneurysms (AAA). The most promising candidates with the highest diagnostic values are plasma D-dimers and markers of activated neutrophils, i.e.
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- - This study examines lesioned fascicles in the sciatic nerves of people with diabetic neuropathy (DN) to understand how these lesions relate to clinical symptoms and their underlying mechanisms.
- - Using advanced imaging and proteomic analysis, researchers found that only individuals with type 2 diabetes (T2D) had these lesions, which showed significant damage like axonal degeneration and demyelination, along with a compromised blood nerve barrier (BNB).
- - The results indicate that while non-lesioned fascicles from T2D donors showed neuroprotective responses, lesioned ones did not and had increased inflammatory activity, suggesting a harmful connection between the liver and nerves that could be targeted for therapy.
The aim of this study was to investigate histopathological differences in abdominal aortic aneurysms (AAAs) between patients with multiple and single arterial aneurysms, as we suspect that there are different underlying mechanisms in aneurysm formation. Analysis was based on a previous retrospective study on patients with multiple arterial aneurysms (; defined as at least four, = 143) and a single AAA (, = 972) who were admitted to our hospital for treatment between 2006 and 2016. Available paraffin-embedded AAA wall specimens were derived from the Vascular Biomaterial Bank Heidelberg (, = 12 vs.
View Article and Find Full Text PDFThere is increasing evidence for enhanced oxidative stress in the vascular wall of abdominal aortic aneurysms (AAA). Mitochondrial damage and dysfunction are hypothesized to be actors in altered production of reactive oxygen species (ROS) and oxidative stress. However, the role of mitochondria and oxidative stress in vascular remodelling and progression of AAA remains uncertain.
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- The study aimed to compare patients with multiple arterial aneurysms to those with single aneurysms, focusing on factors like age, sex, and location of the aneurysms.
- Out of 3107 patients reviewed, 2189 were included, with 143 having multiple aneurysms and a significant difference in average age at diagnosis between the two groups.
- Findings revealed that patients with multiple aneurysms were generally younger and had different common locations for their aneurysms, confirmed by a follow-up study at another institution.