Publications by authors named "S Vincenzo"
Increased oxidative stress within the airways is associated to epithelial damage and amplification of inflammatory responses that in turn contribute to Chronic Obstructive Pulmonary Disease (COPD) progression. This study was aimed to identify whether a new formulation of N-acetylcisteine (NAC), carnitine, curcumin and B2 vitamin could counteract oxidative stress and downstream pro-inflammatory events promoted by cigarette smoke extract (CSE) exposure in primary bronchial epithelial cells (PBEC), both submerged/undifferentiated (S-PBEC) and cultured at the air-liquid interface (ALI-PBEC). PBEC were exposed to CSE with/without the new formulation or NAC alone and ROS production, IL-8 and IL-6 gene expression and protein release were evaluated.
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- Very high-power short-duration (vHPSD) radiofrequency ablation for pulmonary vein isolation shows reduced ablation times and better patient tolerance compared to traditional methods.
- In a study of 58 patients undergoing vHPSD, results indicated significantly shorter procedural and RF times, along with reduced need for anesthetic drugs compared to a control group.
- The vHPSD method allowed for effective PV isolation under mild conscious sedation, with a notably lower pain experience reported by patients.
Cigarette smoke (CS) is a major risk factor for chronic lung diseases and promotes activation of pattern recognition receptors in the bronchial epithelium. NOD-like receptor family, pyrin domain-containing 3 (NLRP3) is a pattern recognition receptor whose activation leads to caspase-1 cleavage, maturation/release of IL-1β and IL-18, and eventually pyroptosis. Whether the NLRP3 inflammasome participates in CS-induced inflammation in bronchial epithelial cells is still unclear.
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- The study looked at how otolaryngologists (ear, nose, and throat doctors) can help people who have nosebleeds that just won't stop. They wanted to see if tying off or burning a certain artery (the sphenopalatine artery) would work well and safely over time.
- Researchers reviewed 16 different studies with 454 patients; about two-thirds had the artery tied off, and the rest had it burned or both.
- The results showed only a small number of patients had nosebleeds return or other complications, making these methods seem safe and helpful for stubborn nosebleeds.
Notch-1 signaling plays a crucial role in stem cell maintenance and in repair mechanisms in various mucosal surfaces, including airway mucosa. Persistent injury can induce an aberrant activation of Notch-1 signaling in stem cells leading to an increased risk of cancer initiation and progression. Chronic inflammatory respiratory disorders, including chronic obstructive pulmonary disease (COPD) is associated with both overactivation of Notch-1 signaling and increased lung cancer risk.
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