Trehalose Inhibits ferroptosis Through Activating SIRT3/SOD2 Signaling Axis and Alleviates Brain Injury After Traumatic Brain Injury.

Trehalose has neuroprotective effects in neurodegenerative diseases. This study aimed to explore the impact of trehalose on traumatic brain injury (TBI) by investigating its role in neuroprotection. The TBI mice model was established utilizing the cortical impact technique followed by trehalose treatment.

Machine Learning-Assisted Biomass-Derived Carbon Dots as Fluorescent Sensor Array for Discrimination of Warfarin and Its Metabolites.

Warfarin (WAR), an effective oral anticoagulant, is of utmost importance in treating many diseases. Despite its significance, rapid and precise discrimination of WAR remains a formidable challenge, especially facing its structural analogs of metabolites. Here, three kinds of herb-derived N-doped carbon dots (NCDs) were greenly synthesized via a fast and simple microwave-assisted method.

The Relationship Between Gut Microbiota, Muscle Mass and Physical Function in Older Individuals: A Systematic Review.

Background: Recent evidence suggests that sarcopenia and subsequent changes in muscle mass and functional outcomes are linked to disruption to the gastrointestinal microbiota composition and/or function via the microbiota-gut-muscle axis. Despite growing interest, few studies have systemically analysed (1) the relationship between the gut microbiota, muscle mass and physical performance and (2) the effects of gut-modulating dietary interventions on these outcomes within older individuals with or without sarcopenia.

Methods: Four electronic databases (PubMed, MEDLINE, Embase and Scopus) were searched for articles published from the year 2004 until July 2023.

Forging-Submerged Arc Additive Hybrid Manufacturing of the Mn-Mo-Ni Component: In Situ Reheat Cycles Inducing the Homogenization of the HAZ Microstructure.

Forging additive hybrid manufacturing integrated the high efficiency of forging and the great flexibility of additive manufacturing, which has significant potential in the construction of reactor pressure vessels (RPVs). In the components, the heat-affected zone (HAZ, also called as bonding zone) between the forged substrate zone and the arc deposition zone was key to the final performance of the components. In this study, the Mn-Mo-Ni welding wire was deposited on the 16MnD5 substrate with a submerged arc heat source.

Interface Enhancement and Tribological Properties of Cattle Manure-Derived Corn Stalk Fibers for Friction Materials: The Role of Silane Treatment Concentration.

Corn stalk fibers extracted from cattle manure (CSFCM) represent a unique class of natural fibers that undergo biological pre-treatment during ruminant digestion. This study systematically investigates the optimization of CSFCM-reinforced friction materials through controlled silane treatment (2-10 wt.%).