Developing a clinical trial unit to advance research in an academic institution.

Research, clinical care, and education are the three cornerstones of academic health centers in the United States. The research climate has always been riddled with ebbs and flows, depending on funding availability. During a time of reduced funding, the number and scope of research studies have been reduced, and in some instances, a field of study has been eliminated.

Frequency of unrecognized Bordetella pertussis infections in adults.

To investigate the frequency of unrecognized Bordetella pertussis infections in adults, we performed IgA and IgG ELISA antibody studies with four B. pertussis antigens--i.e.

Prolonged postpartum anovulation in mastectomized cows requires tactile stimulation by the calf.

Association of the calf with its dam prolongs the postpartum interval to first ovulation in intact and mastectomized cows indicating that tactile stimulus of the teat and (or) udder is not necessary. Therefore, we conducted the following experiment to determine whether individual calves allowed restricted contact with their mastectomized dam would delay the onset of first postpartum ovulation. Mastectomized cows (n = 21) were allotted randomly and equally to three groups in which cows were 1) allowed unrestricted access to their calves, with unlimited tactile, olfactory, visual, and auditory stimuli (calf present); 2) removed permanently from their calves 24 h after parturition and provided no further association with their calves (calf removed); and 3) remained with their calves for 24 h and then the cow-calf pair was restricted to a pen where tactile contact of the calf was limited to the head and neck region of its dam (calf restricted).

Cow-calf association delays postpartum ovulation in mastectomized cows.

Eleven 3-yr-old crossbred Angus cows that had raised one calf each were mastectomized at 6 to 7 mo of their second gestation. All calves were removed from cows within 12 h after birth. Cows were kept in a drylot with a fertile bull for 60 d after parturition.

Occupational risk of HIV, HBV and HSV-2 infections in health care personnel caring for AIDS patients.

We have prospectively followed for 9-12 months, 246 female health care workers (HCWs): 102 with high exposure (HE), 43 with low exposure (LE), and 101 with no exposure (NE) to AIDS (acquired immunodeficiency syndrome) patients. No HCWs have clinical, serologic, or immunologic evidence of HIV (human immunodeficiency virus) infection. No HCWs in the HE group seroconverted to cytomegalovirus (CMV).