Publications by authors named "S Vigano"
Article Synopsis
- Two patients developed severe hypophosphatemia requiring hospitalization after denosumab treatment for osteoporosis, despite having normal kidney function and no known risk factors.
- Both patients experienced neurological symptoms and severe fatigue, which improved with intravenous phosphate treatment, and they left the hospital with oral phosphate and vitamin D supplements.
- As denosumab use increases, it's important to monitor serum phosphate and related levels regularly, and to consider hypophosphatemia as a potential issue when patients report unexplained fatigue or muscle problems.
This article addresses the evolving state of lutetium-177 radiopharmaceutical therapies in Italy, focusing on the importance of the definition of patient management practices regarding the approved treatments based on [177Lu]Lu-DOTATATE for neuroendocrine tumors and [177Lu]Lu-PSMA-617 for metastatic castration-resistant prostate cancer. Italian medical facilities are facing new challenges with the increase in the demand for such therapies while transitioning from restrictive hospitalization requirements to more flexible outpatient options. Therefore, four management strategies are described here, varying from immediate discharge after the administration to 24-h hospitalization, and their environmental and radiation safety implications are evaluated through simple models aimed at assessing the effective doses on the local population and wastewater purification plant workers.
View Article and Find Full Text PDFAneuploidy is a hallmark of human cancer, yet the molecular mechanisms to cope with aneuploidy-induced cellular stresses remain largely unknown. Here, we induce chromosome mis-segregation in non-transformed RPE1-hTERT cells and derive multiple stable clones with various degrees of aneuploidy. We perform a systematic genomic, transcriptomic and proteomic profiling of 6 isogenic clones, using whole-exome DNA, mRNA and miRNA sequencing, as well as proteomics.
View Article and Find Full Text PDFAneuploidy results in a stoichiometric imbalance of protein complexes that jeopardizes cellular fitness. Aneuploid cells thus need to compensate for the imbalanced DNA levels by regulating their RNA and protein levels, but the underlying molecular mechanisms remain unknown. In this study, we dissected multiple diploid versus aneuploid cell models.
View Article and Find Full Text PDFArticle Synopsis
- The systematic review evaluated the status of new robotic systems approved for urological surgery, focusing on their evolution based on the IDEAL framework.
- It found 74 studies, with 90.5% being noncomparative, while only one randomized trial compared the KangDuo system with the da Vinci system.
- Results showed that the new robotic platforms had similar outcomes to the da Vinci system, but the review highlighted limitations like small sample sizes and the lack of robust comparative studies.