Publications by authors named "S Vieweg"
Article Synopsis
- - The study investigates how animals balance their desire to explore with their need for safety, focusing on the role of brain circuits in regulating movement and motivation.
- - Researchers identified a specific glutamatergic pathway from the medial septum and diagonal band of Broca to the ventral tegmental area that influences exploratory behaviors in mice.
- - Using machine learning, the team demonstrated that activating this pathway leads to increased exploratory actions, suggesting it plays a critical role in initiating locomotion and exploration-related behaviors.
Article Synopsis
- The N-terminal domain (Nt17) of the Huntingtin protein is crucial for regulating its aggregation and toxicity, particularly in relation to the length of the polyQ repeat.
- Removing or altering Nt17 affects Httex1's aggregation, reduces cell inclusions, enhances neuronal uptake, and can prevent cell death in models of Huntington's disease.
- The findings suggest that Nt17 is a central regulator in the behavior of Httex1, making it a potential target for therapies aimed at reducing Huntingtin-related neurotoxicity.
The disruptive event of the COVID-19 pandemic appearing in 2020 changed the rules of how international supply chains and businesses perform. The pandemic took most of the countries and organisations by surprise, with the tragic consequences of 203 million infections and almost 4,5 million deaths worldwide until August 2021. This paper deals with the consequences of the pandemic relating to international distributed manufacturing.
View Article and Find Full Text PDFLoss of function mutations in the PTEN-induced kinase 1 (PINK1) kinase are causal for autosomal recessive Parkinson's disease (PD) whilst gain of function mutations in the LRRK2 kinase cause autosomal dominant PD. PINK1 indirectly regulates the phosphorylation of a subset of Rab GTPases at a conserved Serine111 (Ser111) residue within the SF3 motif. Using genetic code expansion technologies, we have produced stoichiometric Ser111-phosphorylated Rab8A revealing impaired interactions with its cognate guanine nucleotide exchange factor and GTPase activating protein.
View Article and Find Full Text PDFArticle Synopsis
- Increasing evidence indicates that amyloid polymorphism leads to various strains of amyloids with different toxicities and pathologies, but validating this is difficult due to the lack of effective diagnostic tools.
- Researchers developed gold nanoparticles coated with 11-mercapto-1-undecanesulfonate that can effectively label amyloid fibrils from synthetic, recombinant, and native sources.
- The use of these nanoparticles with cryogenic transmission electron microscopy reveals unique morphological features of amyloid fibrils, highlighting significant differences in fibril structure from human tissue compared to in vitro models, and supports the idea that the biological environment affects amyloid strain characteristics.