Publications by authors named "S Vicent"
Background: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with limited treatment options and a poor prognosis. The critical role of epigenetic alterations such as changes in DNA methylation, histones modifications, and chromatin remodeling, in pancreatic tumors progression is becoming increasingly recognized. Moreover, in PDAC these aberrant epigenetic mechanisms can also limit therapy efficacy.
View Article and Find Full Text PDFBackground: The identification of novel therapeutic strategies to overcome resistance to the MEK inhibitor trametinib in mutant KRAS lung adenocarcinoma (LUAD) is a challenge. This study analyzes the effects of trametinib on Id1 protein, a key factor involved in the KRAS oncogenic pathway, and investigates the role of Id1 in the acquired resistance to trametinib as well as the synergistic anticancer effect of trametinib combined with immunotherapy in KRAS-mutant LUAD.
Methods: We evaluated the effects of trametinib on KRAS-mutant LUAD by Western blot, RNA-seq and different syngeneic mouse models.
Article Synopsis
- Drug-target interaction (DTI) prediction is crucial for drug repurposing but is currently hindered by expensive computational methods and poor generalization to new datasets.
- The paper introduces GeNNius, a Graph Neural Network-based method that not only enhances accuracy and efficiency in DTI prediction but also uncovers new drug-target interactions.
- GeNNius maintains biological relevance in its data representation and is available for public use on GitHub, promising improvements in DTI prediction capabilities.
Drug combinations are key to circumvent resistance mechanisms compromising response to single anti-cancer targeted therapies. The implementation of combinatorial approaches involving MEK1/2 or KRASG12C inhibitors in the context of KRAS-mutated lung cancers focuses fundamentally on targeting KRAS proximal activators or effectors. However, the antitumor effect is highly determined by compensatory mechanisms arising in defined cell types or tumor subgroups.
View Article and Find Full Text PDFArticle Synopsis
- Diffuse intrinsic pontine glioma (DIPG) is a serious brain tumor and is the most common cause of cancer deaths in kids.
- Scientists found that a protein called TIM-3 is present in both the tumor cells and nearby cells, which may help the tumor grow.
- By blocking TIM-3, they noticed that it helped some mice live longer and fight off the tumor, showing it could be a good target for new treatments for DIPG.