Publications by authors named "S Vetrivel"
Polymorphism in the Drug Transporter Gene ABCB1 as a Potential Disease Modifier in Cortisol-Producing Adrenal Adenomas.
Exp Clin Endocrinol Diabetes
November 2024
Article Synopsis
- Endogenous hypercortisolism shows different symptoms, and researchers are seeking to understand what factors influence its severity, especially focusing on the ABCB1 gene's role in glucocorticoid secretion.
- The study examined 137 patients from the German Cushing's registry to see how the ABCB1 polymorphism rs2032582 affects steroid levels and clinical characteristics.
- Results showed that patients with cortisol-producing adrenal adenomas who had the major allele GG of the ABCB1 polymorphism had higher cortisol levels and blood pressure compared to those with other genotype variations, suggesting the gene may influence disease severity.
Article Synopsis
- Monocrystalline bulk silicon has been the go-to material for MEMS sensors, but there's a rising interest in alternative piezoresistive materials for miniaturized, high-sensitivity applications.
- Silicon nanowires (SiNWs) are gaining attention for their nanoscale size, high piezoresistive coefficients, and suitability for integrated circuit processes.
- This review discusses the fundamentals of piezoresistance, compares ungated and gated SiNWs, and highlights their applications in various MEMS sensors like pressure, acceleration, and flow sensors.
PPARG dysregulation as a potential molecular target in adrenal Cushing's syndrome.
Front Endocrinol (Lausanne)
December 2023
Background: We performed a transcriptomic analysis of adrenal signaling pathways in various forms of endogenous Cushing's syndrome (CS) to define areas of dysregulated and druggable targets.
Methodology: Next-generation sequencing was performed on adrenal samples of patients with primary bilateral macronodular adrenal hyperplasia (PBMAH, n=10) and control adrenal samples (n=8). The validation groups included cortisol-producing adenoma (CPA, n=9) and samples from patients undergoing bilateral adrenalectomy for Cushing's disease (BADX-CD, n=8).
Introduction: Adrenal vein sampling (AVS) is not a routine procedure in patients with primary bilateral macronodular adrenocortical hyperplasia (PBMAH), but has been used to determine lateralization of cortisol secretion in order to guide decision of unilateral adrenalectomy. Our aim was to characterize the steroid fingerprints in AVS samples of patients with PBMAH and hypercortisolism and to identify a reference hormone for AVS interpretation.
Method: Retrospectively, we included 17 patients with PBMAH from the German Cushing's registry who underwent AVS.
The posttranscriptional modifications (PTM) of the Histone H3 family play an important role in ocular system differentiation. However, there has been no study on the nature of specific Histone H3 subtype carrying these modifications. Fortuitously, we had previously identified a dominant small-eye mutant Aey69 mouse with a mutation in the H3.
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