Geraniin: A dietary ellagitannin as a modulator of signalling pathways in cancer progression.

Cancer remains a global health challenge, necessitating the exploration of novel therapeutic agents. Current treatment options are unable to overwhelm and cure the cancer burden. Hence, identifying new bioactive molecular entities with potent anticancer activity is the need of the hour.

Beyond Hormones: Investigating the Impact of Progesterone Receptor Membrane Component 1 in Lung Adenocarcinoma.

Progesterone Receptor Membrane Component 1 (PGRMC1) is a candidate oncogene with a prominent involvement in the pathogenesis of diverse cancers (ovarian, thyroid, breast, colon, head, and neck). Our study ascertains the ability of PGRMC1 to influence WNT members in the non-small cell lung cancer subtype-lung adenocarcinoma (LUAD) and participates in augmented cell proliferation and migration. Both computational and in vitro experimental analyses were performed in this study.

Methyl gallic acid entrapped ethosomal nano-vesicular system augments cytotoxicity against squamous cell carcinoma.

Unlabelled: Methylated gallic acid (MGA) is a potent anticancer biomolecular entity (BME). Loading MGA into a nano-vesicular (NV) drug delivery system using nanotechnology approaches can increase the efficiency of the drug and its release characteristics. This study aimed to develop an ethosomal nano-vesicular (ENV) system loaded with MGA that shows augmented entrapment efficiency, release rate, and cytotoxic potential against oral cancer.

Cancer stem cell markers interplay with chemoresistance in triple negative breast cancer: A therapeutic perspective.

Triple-negative breast cancer (TNBC) is one of the most fatal and aggressive type of cancer in younger population. TNBC is poorly diagnosed, detected only at later stages with low survival rate and high chemoresistance. The expression of the cancer stem cell (CSC) markers has critical role in chemoresistance and recurrence.