Publications by authors named "S Vellaichamy"
Article Synopsis
- Intraoperative hypothermia during breast reconstruction surgery may lead to increased wound healing complications, despite advancements in surgical techniques.
- A comprehensive review of existing studies showed that hypothermia resulted in a statistically significant increase in the risk of wound issues, with a risk ratio of 1.68.
- While hypothermia did not significantly affect the rates of infection, hematoma, seroma, or necrosis, it remains a pertinent risk factor that needs to be considered in surgical practices.
Glucose-conjugated glutenin nanoparticles for selective targeting and delivery of camptothecin into breast cancer cells.
Naunyn Schmiedebergs Arch Pharmacol
October 2023
Receptor-mediated drug delivery systems are a promising tool for targeting malignant cells to suppress/inhibit the malignancy without disturbing healthy cells. Protein-based nanocarrier systems possess numerous advantages for the delivery of variety of chemotherapeutics, including therapeutic peptides and genes. In the present work, glucose-conjugated camptothecin-loaded glutenin nanoparticles (Glu-CPT-glutenin NPs) were fabricated to deliver camptothecin to MCF-7 cells via GLUT-1 transporter protein.
View Article and Find Full Text PDFBackground: Cervical cancer is one of the leading causes of female death, with a mortality rate of over 200,000 per year in developing countries. Despite a decrease in cervical cancer occurrences in developed countries over the last decade, the frequency of the disease in developing nations continues to rise at an alarming rate, particularly when it is linked to the human papillomavirus (HPV). With just a few highly invasive conventional therapies available, there is a clear need for novel treatment options such as nanotechnology-based chemotherapeutic drug delivery.
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- Enhanced cancer treatment research is crucial due to the rising cancer death rates, despite existing treatment options, with challenges including vaccine availability and cancer recurrence in previously treated patients.
- Current strategies involve surgical removal, radiation, and combined therapies like immunotherapy and chemotherapy, but issues like radio-resistance and drug toxicity persist due to damage to both cancerous and healthy cells.
- Emerging targeted therapies focus on specific surface receptors of cancer cells to improve drug delivery effectiveness, highlighting advancements in receptor-mediated approaches for better therapeutic outcomes.
Lower doses of capsaicin (8-methyl-N-vanillyl-6-nonenamide) have the potential to serve as an anticancer drug, however, due to its pungency, irritant effect, poor water solubility and high distribution volume often linked to various off-target effects, its therapeutic use is limited. This study aimed to determine the biodistribution and anticancer efficacy of capsaicin loaded solid lipid nanoparticles (SLNs) in human hepatocellular carcinoma in vitro. In this study, SLNs of stearic acid loaded with capsaicin was formulated by the solvent evaporation-emulsification technique and were instantly characterized for their encapsulation efficiency, morphology, loading capacity, stability, particle size, charge and in vitro drug release profile.
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