Mild Cognitive Impairment in Patients with Early-Onset Parkinson's Disease.

Background/aims: Few studies have described mild cognitive impairment (MCI) and cognitive characteristics in early-onset Parkinson's disease (EOPD). This study describes attention/working memory, language, memory, visuospatial abilities, executive function, and frequency of MCI and dementia in EOPD.

Methods: Eighty-one EOPD patients were administered neuropsychological tests and the Beck Depression Inventory.

Parkinson disease and progressive supranuclear palsy: protein expression in skin.

Objective: This study characterizes the expression of tau (p-tau) and α-synuclein (α-syn) by immunohistochemistry in the skin of three different populations: healthy control (HC), Parkinson disease (PD), and progressive supranuclear paralysis (PSP) subjects, with the purpose of finding a biomarker that could differentiate between subjects with PD and PSP.

Material And Methods: We evaluated the presence of p-tau and α-syn in a pilot study in the skin of three distinct groups of patients: 17 healthy subjects, 17 patients with PD, and 10 patients with PSP. Four millimeters punch biopsies were obtained from the occipital area and analyzed by immunohistochemistry using antibodies against α-syn and phosphorylated species of tau.

Frequency and clinical correlates of postural and striatal deformities in Parkinson's disease.

Objective: To assess the frequency of postural and striatal deformities in patients with Parkinson's disease.

Patients And Methods: A total of 416 consecutive patients with Parkinson's disease were evaluated for musculoskeletal deformities using a standardized criteria. Data including disease history, motor complications and antiparkinsonic treatment were collected.

[Prevalence, associated factors and phenomenology of psychosis in patients with Parkinson's disease].

Introduction: Psychosis associated with Parkinson's disease is a major neuropsychiatric complication; it has been reported that 60% of patients will develop psychosis during the disease evolution. Its pathophysiology is multifactorial and clinically psychotic phenomena include minor hallucinations and confusional states.

Material And Methods: We performed a cross-sectional study in patients with Parkinson's disease from a tertiary hospital using a thoughtful neurological and neuropsychiatric evaluation along with specific scales for non-motor symptoms, depression, cognition, and presence and severity of psychotic symptoms and hallucinations.

Independent Validation of the SEND-PD and Correlation with the MDS-UPDRS Part IA.

Introduction. Neuropsychiatric symptoms in Parkinson's disease can be assessed by the MDS-UPDRS part IA. The Scale for Evaluation of Neuropsychiatric Disorders in Parkinson's disease (SEND-PD) has been recently developed to assess the severity of some neuropsychiatric symptoms.