Publications by authors named "S Vazquez Agosto"
Article Synopsis
- Fibroblast heterogeneity significantly impacts cancer progression, making it crucial to understand different fibroblast types for developing effective cancer treatments.
- In pancreatic ductal adenocarcinoma (PDAC), cancer-associated fibroblasts (CAFs) are the predominant cell type, and the study identifies how the MAPK signaling pathway influences their differentiation into specific phenotypes.
- The study introduces a novel "mapCAF" phenotype associated with certain tumor cells and immune response characteristics, suggesting that targeting these specific CAFs could improve treatment strategies for various cancers.
Article Synopsis
- The study examines the role of SEMA3A, an axon guidance cue, in pancreatic ductal adenocarcinoma (PDAC) progression, highlighting its expression in different PDAC cell types and its impact on cellular behaviors.
- Researchers combined transcriptomic data and experimental approaches to demonstrate that SEMA3A contributes to aggressive cancer traits, including enhanced cell migration and resistance to cell death.
- Findings suggest that SEMA3A promotes a tumor-favorable environment by attracting macrophages and skewing them towards a pro-tumor, M2-like state, while potentially inhibiting effective immune responses from T cells.
Long-term organoid culture of a small intestinal neuroendocrine tumor.
Front Endocrinol (Lausanne)
April 2023
Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are rare and highly heterogeneous neoplasms whose incidence has markedly increased over the last decades. A grading system based on the tumor cells' proliferation index predicts high-risk for G3 NETs. However, low-to-intermediate grade (G1/G2) NETs have an unpredictable clinical course that varies from indolent to highly malignant.
View Article and Find Full Text PDFMultiple rural states and communities experience elevated rates of human immunodeficiency virus (HIV), often associated with diminished healthcare access and increased drug use. Though a substantial proportion of rural populations are sexual and gender minorities (SGM), little is known of this group regarding substance use, healthcare utilization, and HIV transmission behaviors. During May-July 2021, we surveyed 398 individuals across 22 rural Illinois counties.
View Article and Find Full Text PDFArticle Synopsis
- Transcriptomic analyses have identified two main types of pancreatic ductal adenocarcinoma (PDAC), each with different biology and clinical outcomes, emphasizing the need to understand the roles of FGFR1 and FGFR4 in aggressive PDAC forms.
- FGFR4 expression is high in the classical PDAC subtype, correlating with better patient outcomes, while its downregulation in aggressive basal-like/squamous PDAC is linked to gene hypermethylation and decreased transcription marks.
- In contrast, FGFR1 is widely expressed in various pancreatic tissues and associated with the epithelial-mesenchymal transition (EMT) but not with the aggressive subtype, suggesting that FGFR4 can be a key marker for classifying PD