Intranasal liposomal remdesivir induces SARS-CoV-2 clearance in K18-hACE2 mice and ensures survival.

A huge challenge after the emergence of COVID-19 has been the discovery of effective antiviral drugs. Although remdesivir (RDV) emerged as one of the most promising drugs, its pharmaceutical formulation Veklury® is limited by moderate efficacy, high toxicity and need for parenteral administration. The aim of the present work was to develop a liposomal formulation of RDV for pulmonary administration and evaluate its efficacy in models of COVID-19.

Variation in the diet composition and weight-length relationship of small characids in urbanized and forested streams.

The diet of indicator fish species plays a crucial role in assessing ecosystem health. This study evaluated streams with and without urban influences, focusing on abiotic parameters and the trophic ecology of Psalidodon fasciatus and Piabina argentea. Forested streams exhibited higher redox potential, dissolved oxygen, transparency, and depth, whereas urban streams had higher temperatures, greater widths, and increased levels of total dissolved solids, conductivity, total coliforms, and thermotolerant coliforms.

Phylogeography, taxonomy, and conservation of the endangered brown howler monkey, (Primates, Atelidae), of the Atlantic Forest.

The brown howler, , endemic to the Atlantic Forest of Brazil and Argentina, is threatened by habitat loss and fragmentation, hunting, and its susceptibility to yellow fever. Two subspecies have been recognized, but their names, validity, and geographic ranges have been controversial. We obtained samples covering the species' entire distribution in Brazil and Argentina to clarify these issues by investigating their genetic diversity and structure and assessing their evolutionary history.

Use of Lipidic Extracts in the Development of Healthier Pastry Products with Reduced Fat Contents.

Pastry products constitute a significant segment of the food market. However, the high amount of fat used in their production poses a challenge when competing for the attention of modern consumers, who are more conscious of the health problems associated with the consumption of high-fat products. With this in mind, the main objective of this study is the reduction of the total fat and saturated fat contents of two bakery products, brioche-type bread and rice cake, by partial substitution of the main fat source with lipid extracts obtained through non-thermal high-pressure extraction (HPE).

Climb forest, climb: diverse disperser communities are key to assist plants tracking climate change on altitudinal gradients.

Climate change is forcing species to shift their distribution ranges. Animal seed dispersers might be particularly important in assisting plants tracking suitable climates to higher elevations. However, this role is still poorly understood due to a lack of comprehensive multi-guild datasets along elevational gradients.