Publications by authors named "S Vaulont"
is a leading cause of life-threatening invasive infections with up to 40% mortality rates in hospitalized individuals despite antifungal therapy. Patients with chronic liver disease are at an increased risk of candidemia, but the mechanisms underlying this susceptibility are incompletely defined. One consequence of chronic liver disease is attenuated ability to produce hepcidin and maintain organismal control of iron homeostasis.
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- * Researchers discovered that the hormone hepcidin is highly expressed in the skin of psoriasis patients, particularly those with treatment-resistant pustular forms.
- * In experiments with mice, high levels of hepcidin in skin cells caused excessive skin growth and immune cell attraction, suggesting hepcidin plays a key role in psoriasis and could be a target for new treatments.
Article Synopsis
- Cancers evade the immune system, and effective immunotherapies, especially those targeting PD1, work by enhancing T-cell functions, particularly IFNγ production.
- While immunotherapies have improved patient outcomes, not everyone responds, necessitating alternative treatments to enhance their effectiveness.
- The study shows that iron supplementation boosts T-cell responses and enhances the effectiveness of anti-PD1 therapy in mice, indicating that combining iron with immunotherapy could improve cancer treatment outcomes.
This controlled study investigated metabolic changes in non-vaccinated individuals with Long-COVID-19, along with their connection to the severity of the disease. The study involved 88 patients who experienced varying levels of initial disease severity (mild, moderate, and severe), and a control group of 29 healthy individuals. Metabolic risk markers from fasting blood samples were analyzed, and data regarding disease severity indicators were collected.
View Article and Find Full Text PDFThe role of iron in the two major sites of adaptive thermogenesis, namely the beige inguinal (iWAT) and brown adipose tissues (BAT) has not been fully understood yet. Body iron levels and distribution is controlled by the iron regulatory peptide hepcidin. Here, we explored iron homeostasis and thermogenic activity in brown and beige fat in wild-type and iron loaded Hepcidin KO mice.
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