Publications by authors named "S Vassilopoulou"
Cluster headache (CH), a highly disabling condition, lacks disease-specific, mechanism-based prophylactic treatment. Galganezumab, a monoclonal antibody targeting the calcitonin gene-related peptide, reduced the weekly attacks of CH in one randomized, placebo-controlled trial for the prevention of episodic CH (eCH), but this effect was not detected in people with chronic CH (cCH). In this case series, we systematically monitored the efficacy and safety outcomes of adjunctive therapy in 11 people with refractory CH (failure of ≥ 3 prophylactic treatments; eCH = 5, cCH, = 6) who received galcanezumab (120-360 mg monthly) for 3 consecutive months.
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- Intracranial atherosclerotic disease (ICAD) is a major cause of ischemic stroke globally, with rising detection rates across various racial and ethnic groups, shifting our understanding of its epidemiology.
- The disease is characterized by the buildup of plaques in major intracranial arteries, with diagnosis relying on the degree of luminal narrowing, which can now be detected earlier using advanced imaging techniques like high-resolution vessel wall MRI.
- Recent studies show that while historically certain racial groups had higher ICAD prevalence, there is an increasing recognition of the condition among White patients, raising the need for tailored management strategies that address risk factors and emerging treatments.
Article Synopsis
- Autoimmune GFAP astrocytopathy is a neurological disorder characterized by antibodies attacking GFAP, leading to symptoms like headaches, visual issues, and psychiatric disturbances, often manifesting as meningoencephalitis.
- The condition may be triggered by neoplasms or viral infections, and about 20-30% of patients experience relapses after initial treatment, which responds favorably to steroids.
- The review includes two case studies, explores the role of anti-GFAP antibodies, and discusses clinical features, imaging findings, and treatment strategies for this emerging disorder.
Background And Purpose: Cervical artery dissection (CAD) represents a leading cause of unilateral lower cranial nerve IX-XII palsy, known as Collet-Sicard syndrome (CSS). High-resolution magnetic resonance imaging (HR-MRI) is widely used in the evaluation of patients with CAD, providing information regarding vessel wall abnormalities and intraluminal thrombus.
Methods: We present a patient with palsy of multiple lower cranial nerves in the context of CSS, attributed to unilateral spontaneous internal carotid artery dissection.
Introduction: Silent pauses are regarded as integral components of the temporal organization of speech. However, it has also been hypothesized that they serve as markers for internal cognitive processes, including word access, monitoring, planning, and memory functions. Although existing evidence across various pathological populations underscores the importance of investigating silent pauses' characteristics, particularly in terms of frequency and duration, there is a scarcity of data within the domain of post-stroke aphasia.
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