Publications by authors named "S Vashee"
Article Synopsis
- Researchers successfully created an infectious clone of HSV-1 by assembling its genome from 11 cloned fragments in yeast using a method called transformation associated recombination.* -
- They engineered mutations in five specific genes, which are important for the virus's structure and functionality, and discovered that certain combinations of these mutations led to "synthetic lethality," preventing the virus from replicating in specific cell lines.* -
- The study focused on the mutations of the UL16 and UL21 genes, revealing that viruses lacking both proteins showed immature capsid structures unable to mature into infectious particles, highlighting their potential roles in virus assembly.*
: Breast cancer is diagnosed in 2.3 million women each year and kills 685,000 (~30% of patients) worldwide. The prognosis for many breast cancer subtypes has improved due to treatments targeting the estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2).
View Article and Find Full Text PDFSocieties with exposure to preindustrial diets exhibit improved markers of health. Our study used a comprehensive multi-omic approach to reveal that the gut microbiome of the Ju/'hoansi hunter-gatherers, one of the most remote KhoeSan groups, exhibit a higher diversity and richness, with an abundance of microbial species lost in the western population. The Ju/'hoansi microbiome showed enhanced global transcription and enrichment of complex carbohydrate metabolic and energy generation pathways.
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- Extrapulmonary tuberculosis (EPTB) is a serious public health issue that often gets overlooked, so this study examines its genetic diversity, drug resistance, and transmission chains in western Ethiopia.
- Using whole-genome sequencing on samples from EPTB patients, researchers found that 87.64% of the bacteria belonged to a dominant lineage (Lineage-4) with varying sub-lineages, and a low rate of multi-drug resistance was observed.
- The study highlights a high clustering rate of infections, signaling the need for better TB control measures, and reveals that many drug-resistance mutations were not detected by standard diagnostic tests, showing the importance of advanced sequencing techniques.
Background: The lineage 4 (L4) of Mycobacterium tuberculosis (MTB) is not only globally prevalent but also locally dominant, surpassing other lineages, with lineage 2 (L2) following in prevalence. Despite its widespread occurrence, factors influencing the expansion of L4 and its sub-lineages remain poorly understood both at local and global levels. Therefore, this study aimed to conduct a pan-genome and identify genomic signatures linked to the elevated prevalence of L4 sublineages among extrapulmonary TB (EPTB) patients in western Ethiopia.
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