Factors associated with acute renal failure in severe falciparum [corrected] malaria patients.

Acute renal failure (ARF) is a common cause of morbidity and mortality in severe malaria infection. We evaluated factors associated with acute renal failure in severe malaria by comparing patients with severe malaria with and without ARF admitted to the Hospital for Tropical Diseases, Bangkok, Thailand. Nine hundred fifteen severe malaria patients were included in the study, of whom 195 had ARF and 720 did not have ARF.

Ursodeoxycholic acid and artesunate in the treatment of severe falciparum malaria patients with jaundice.

Background And Aims: Plasmodium falciparum (PF) infection can lead to severe complications. Ursodeoxycholic acid (UDCA) is increasingly used for the treatment of cholestatic liver diseases. The present study aims to determine the effects of combined UDCA and artesunate compared to placebo and artesunate on the improvement of liver tests in severe PF jaundiced patients.

The epidemiology of patients with severe malaria who died at the Hospital for Tropical Diseases, 1991-2004.

This study is a retrospective case series of the causes of death among patients with severe malaria. Data from the medical records of patients who were admitted to the Intensive Care Unit (ICU) of the Hospital for Tropical Diseases, Mahidol University, Bangkok, Thailand between 1991 and 2004 were analyzed. The overall hospital mortality rate was 0.

Curdlan sulphate in human severe/cerebral Plasmodium falciparum malaria.

Preclinical studies have shown that curdlan sulphate (CRDS), a sulphated 1-->3-beta-D glucan, inhibits Plasmodium falciparum in vitro and down-modulates the immune response. A direct, non-specific effect on cytoadherence and rosetting may be predicted, as has been described with other sulphated polysaccharides, e.g.

Pharmacokinetic investigation on the therapeutic potential of artemotil (beta-arteether) in Thai patients with severe Plasmodium falciparum malaria.

Pharmacokinetic data were obtained to evaluate the therapeutic potential of Artemotil (beta-arteether) in 56 Thai patients with severe Plasmodium falciparum malaria. Intramuscular administration was given at 1) a low dose of 3.2 mg/kg on day 0 and 1.