Publications by authors named "S Vanhatalo"
Article Synopsis
- The study explores how antiepileptic drugs (AEDs) taken by pregnant mothers affect brain activity in children, particularly focusing on those exposed to AEDs in utero compared to those who weren't.
- Researchers analyzed EEG recordings from 6-year-old children to examine differences in cortical activity networks during sleep and their connection to cognitive performance.
- Results indicate that children exposed to AEDs show significant long-lasting changes in brain activity networks, which correlate with neurocognitive performance, suggesting potential risks associated with AED use during pregnancy.
Objective: Electroencephalography (EEG) is widely used for assessing infant's brain activity, and multi-channel recordings support studies on functional cortical networks. Here, we aimed to assess how the number of recording electrodes affects the quality and level of details accessible in studying infant's cortical networks.
Methods: Dense array EEG recordings with 124 channels from N=20 infants were used as the reference, and lower electrode numbers were subsampled to simulate recording setups with 63, 31, and 19 electrodes, respectively.
Objective: Assess the capacity of brain state of the newborn (BSN) to predict neurodevelopment outcomes in neonatal encephalopathy.
Methods: Trends of BSN, a deep learning-based measure translating EEG background to a continuous trend, were studied from a three-channel montage long-term EEG monitoring from a prospective cohort of 92 infants with neonatal encephalopathy and neurodevelopmental outcomes assessed by Bayley Scales of Infant Development, 3rd edition (Bayley-III) at 18 months. Outcome prediction used categories "Severe impairment" (Bayley-III composite score ≤70 or death) or "Any impairment" (score ≤85 or death).
Aim: Opioids might be harmful to the developing brain and dosing accuracy is important. We aimed at investigating fentanyl effects on cortical activity in infants using computational re-analysis of bedside recorded EEG signals.
Methods: Fifteen infants born at median 26.
Objective: Appendicoliths are associated with a more complicated course of acute appendicitis and failure of non-operative treatment. We aimed to update the appendicolith classification originally described in 1966 and to assess the association of appendicolith characteristics with appendicitis severity.
Design: This prospective predefined MAPPAC-trial (ClinicalTrials.