Publications by authors named "S Valentine"
Article Synopsis
- Single cell mass spectrometry (scMS) is a promising technique for analyzing proteins from individual cells, but current methods are limited by high costs and sequential processing that reduce throughput.
- This study introduces a new method that allows for the simultaneous processing of 10 single cells using 3D printed microfluidic devices and a magnetic beads-based workflow, eliminating the need for expensive robotic liquid handlers.
- The method not only shows consistent quantification across samples but also proves effective in distinguishing different cell lines and assessing proteome changes due to drug treatment, making it a significant advance in single cell proteomics.
Article Synopsis
- Excess body weight and other lifestyle factors like diet, inactivity, and stress are linked to chronic diseases, but can be modified through digital interventions.
- The DIRECTION study tests the effectiveness of adding healthcare guidance and peer support to an online wellness platform compared to self-guided use among individuals considered obese.
- Over 16 weeks, the experimental group participates in daily platform use and weekly support sessions, with outcomes focused on weight loss, dietary habits, physical activity, and changes in health-related behaviors.
HIV criminalization laws may discourage HIV testing. We tested whether California's 2018 HIV criminalization law reform increased the likelihood of past-year HIV testing compared to Nevada, which did not reform its HIV criminalization law. We fitted two difference-in-differences logistic regression models: one for all respondents reporting behaviors that increase the chances of getting or transmitting HIV, and one for male respondents reporting these behaviors.
View Article and Find Full Text PDFIn the last few decades, developers of new drugs, biologics, and devices have increasingly leveraged digital health technologies (DHTs) to assess clinical trial digital endpoints. To our knowledge, a comprehensive assessment of the financial net benefits of digital endpoints in clinical trials has not been conducted. We obtained data from the Digital Medicine Society (DiMe) Library of Digital Endpoints and the US clinical trials registry, ClinicalTrials.
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