Publications by authors named "S Vafaei-Nezhad"
Article Synopsis
- Tramadol is a widely used opioid pain reliever that affects pain and can also be used for treating depression and anxiety, but it has potential for causing serious damage to areas of the central nervous system (CNS), particularly the hippocampus.
- The study reviewed articles from 2000 to 2022 to assess how tramadol impacts the CNS, revealing processes like cell death and dysfunction that affect neural cell function.
- The findings suggest that tramadol can lead to a significant decrease in neural cell count and volume, potentially causing neuropsychological issues such as memory problems and cognitive deficits, indicating the need for more research on its effects.
Article Synopsis
- - Methamphetamine (METH) disrupts neurotransmitter activity in the central nervous system, leading to neurotoxicity through various pathways, including increased reactive nitrogen and oxygen species and mitochondrial apoptosis.
- - This study analyzed structural changes in the amygdala of ten male postmortem brains, comparing chronic METH users to control subjects using various scientific techniques like immunohistochemistry and real-time PCR.
- - Results showed METH addiction led to decreased levels of protective proteins and increased inflammation and neurodegeneration in the amygdala, with reactive oxygen species production linked to specific signaling pathways.
Many systemic and ocular diseases cause macular edema (ME). Macular edema is seen in two primary forms; the first is diffuse thickening of the macula, and the other is a macula with a distinct petaloid (cloverleaf) appearance called cystoid macular edema. Macular edema has a known role in the reduction of visual equity, and many options have been proposed for the reversal of this condition.
View Article and Find Full Text PDFTherapeutic Effects of Photobiomodulation Therapy on Multiple Sclerosis by Regulating the Inflammatory Process and Controlling Immune Cell Activity: A Novel Promising Treatment Target.
J Lasers Med Sci
July 2022
Multiple sclerosis (MS) is one of the autoimmune and chronic diseases of the central nervous system; this disease occurs more frequently in young people and women and leads to neurological symptoms. Oxidative stress, inflammatory processes, and oligodendrocyte dysfunction have a pivotal role in the pathophysiology of this disease. Nowadays it is reported that photobiomodulation (PBM) as a non-invasive treatment has neuroprotective potential, but the exact mechanisms are not understood.
View Article and Find Full Text PDFMesenchymal stem cells (MSCs) and mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have been regarded as the beneficial and available tools to treat various hereditary, multifactorial, acute, and chronic diseases. Mesenchymal stem cells can be extracted from numerous sources for clinical purposes while oral cavity-derived mesenchymal stem cells seem to be more effective in neuroregeneration than other sources due to their similar embryonic origins to neuronal tissues. In various studies and different neurodegenerative diseases (NDs), oral cavity mesenchymal stem cells have been applied to prove their promising capacities in disease improvement.
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