Polymorphism Pro₁₂ --Ala of the peroxisome proliferator-activated receptors gamma gene effect on lipid peroxidation and antioxidant defense in patients with type 2 diabetes.

In this research, we discover effect ofpolymorphism rs1801282 of the PPARG gene on the formation oxidative stress in patients with type 2 diabetes, depending on the duration of the disease: till 5 years, 5-10 years and more than 10 years. Activity of lipidperoxidation was assess in terms of diene conjugates (DC) and malonic dealdehid (MDA) and antioxidant system status - the activity of superoxide dismutase (SOD), catalase and the level of a-tocopherol (a-TF). Molecular genetic studies conducted by the method ofpolymerase chain reaction (PCR) in real time.

[The characteristics of individual reactions of the central hemodynamics to trauma].

Experiments with white mongrel male rats subjected to the standard trauma according to Kennon have revealed four types of responses of the central haemodynamics. The minimal mortality rate (31-38% for the first three days) was registered for hyper- and eudynamic types when the heart productivity parameters and atmospheric pressure either exceeded or were almost similar to those of intact animals. A decrease of these parameters (a hypodynamic type) has led to increase of the mortality rate (to 58%), but a sharp (more then 3 times) decrease of the cardiac index was characterized by a progressive increase of the arterial pressure and maximal mortality rate.

[The cyclic nucleotide content of the blood plasma in rabbits administered izadrin].

The influence of cyclic nucleotides system on the rabbit resistance to injection of exogenic sympathomimetic was studied in this experiment. Absolute concentration value and ratio of cAMP to cGMP in animals with different resistance were determined.