Publications by authors named "S V Zhuk"
Article Synopsis
- Primary ciliary dyskinesia (PCD) is a rare genetic disorder that affects cilia movement, leading to chronic respiratory issues, infertility, and laterality defects in about half of the cases; however, genetic understanding in the Russian population is limited.
- This study analyzed 21 Russian families with PCD, using advanced techniques to confirm ciliary anomalies and discover genetic variants in several PCD-related genes, including both common mutations and novel variants likely unique to Russian individuals.
- The research identified specific mutations that affect gene splicing, with one variant (c.2052+3G>T) linked to an ancestral founder mutation in the Udmurt population, highlighting the significance of regional genetic studies in understanding PCD.
Desmin is the main intermediate filament of striated and smooth muscle cells and plays a crucial role in maintaining the stability of muscle fiber during contraction and relaxation cycles. Being a component of Z-disk area, desmin integrates autophagic pathways, and the disturbance of Z-disk proteins' structure negatively affects chaperone-assisted selective autophagy (CASA). In the present study, we focused on alteration of autophagy flux in myoblasts expressing various Des mutations.
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- A series of PEG-substituted fluorophores were developed for fluorescence-guided imaging, especially to identify ureters in surgical settings, emitting light in the near-infrared region (700-800 nm).
- The bis-PEGylation improved fluorescence in water, with optimal PEG chain lengths suggesting effective imaging results in rodent and porcine models.
- The technology enabled real-time ureter visualization up to 120 minutes post-administration and can differentiate from a common surgical dye, indicating potential for enhanced intraoperative tissue color coding.
Delta like canonical notch ligand 4 (Dll4) expression levels in tumors are known to affect the efficacy of cancer therapies. This study aimed to develop a model to predict Dll4 expression levels in tumors using dynamic enhanced near-infrared (NIR) imaging with indocyanine green (ICG). Two rat-based consomic xenograft (CXM) strains of breast cancer with different Dll4 expression levels and eight congenic xenograft strains were studied.
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