[Pharmacokinetic characteristics of ethacizine in patients with disorders of heart rhythm].

Significant differences in values of the volume of ethacizine distribution and clearance at oral administration in patients with myocardial infarction from those in patients with other pathology were established. A considerable decrease of ethacizine bioavailability in myocardial infarction patients was shown.

[Pharmacokinetic characteristics of propranolol in patients with a history of acute myocardial infarct].

Peculiarities of propranolol pharmacokinetics in patients with acute myocardial infarction were determined after oral administration of 80 mg of the drug and compared with control group of patients with stage II hypertensive disease: a significant increase of Cmax, Tmax and AUC without changes of kel and T1/2. A direct linear correlation (r = 0.86, p = 0.