[Succinate salts in solving the «oxygen paradox» of reperfusion].

Reperfusion damage to the cellular structures of tissues in the early post-ischemic period is a consequence of the restoration of blood flow and reoxygenation. Currently, there is no effective treatment for reperfusion metabolic disorders in clinical practice. Over the past decades, biological studies of hypoxia and the role of hypoxia-inducible factor-1α (HIF-1), potentiating succinatoxidase oxidation by signal from the succinate-dependent receptor (GPR91), have significantly improved the understanding of oxygen homeostasis during the period of recovery of blood flow.

Barium-Strontium Titanate/Porous Glass Structures for Microwave Applications.

Based on porous silicate glasses obtained by ion exchange, glass-ceramic materials containing a solid solution of barium-strontium titanate with a dielectric constant of more than 100 at microwaves, were synthesized for the first time. Glass-ceramic structures were studied using X-ray diffraction, secondary electron microscopy, Mössbauer spectroscopy and porometry methods. Electrical characteristics such as permittivity and losses of as-prepared and annealed in oxygen medium samples were also investigated at microwaves.

Optimization of LpxC Inhibitors for Antibacterial Activity and Cardiovascular Safety.

UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC) is a Zn deacetylase that is essential for the survival of most pathogenic Gram-negative bacteria. ACHN-975 (N-((S)-3-amino-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl)-4-(((1R,2R)-2-(hydroxymethyl)cyclopropyl)buta-1,3-diyn-1-yl)benzamide) was the first LpxC inhibitor to reach human clinical testing and was discovered to have a dose-limiting cardiovascular toxicity of transient hypotension without compensatory tachycardia. Herein we report the effort beyond ACHN-975 to discover LpxC inhibitors optimized for enzyme potency, antibacterial activity, pharmacokinetics, and cardiovascular safety.

[Malnutrition: from pathogenesis to current methods for diagnosis and treatment].

Progressive weight loss is a frequent companion to somatic pathology. The risk of death is known to increase dramatically among those with a body mass index of less than 19 kg/m. Even mild weight loss in the presence of severe diseases can have a substantial impact on the course of the disease.

[Effect of prolonged epidupal analgesia on respiratory function after major laparoscopic surgery].

Unlabelled: The article deals with a study of role of epidural analgesia, used as a part of intra- and postoperative analgesia in patients underwent major laparoscopic surgery (gastric resections, pancreas and duodenal resections, hemicolectomy, resections of colon).

Patients And Methods: The study included 127 patients aged 65 ± 13 years. Main group--patients who had undergone extensive and prolonged laparoscopic surgery; comparison group--patients after traditional open surgery.